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Pharmacology

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drnieves's version from 2017-06-20 01:08

Section

Question Answer
ParasympatheticMuscarinic
M1Gq
M1CNS, enteric nervous system
M2Gi
M2Decrease HR and contractility of atria
M3Gq
M3Increase exocrine gland secretions (lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, bronchoconstriction, increase pupillary sphincter muscle contraction (mitosis), ciliary muscle contraction (accommodation).
Sympatheticalpha, beta
a1Gq
a1Increase vascular s.m. contraction, increase pupillary dilator muscle contraction (myadrisis), increase intestinal and bladder sphincter muscle contraction.
a2Gi
a2Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humour production.
B1Gs
B1Increase HR, contractility, renin release and lipolysis.
B2Gs
B2Vasodilation, bronchoconstriction, increase lipolysis and insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humour production.
D1Gs
D1Relaxes renal vascular sm
D2Gi
D2Modulates transmitter release, especially in brain.
H1Gq
H1Increase nasal and bronchial mucus production, vascular permeability, contraction of bronchioles, pruritus, pain
H2Gs
H2Increase gastric secretion
V1Gq
V1Increase sm vascular contraction
V2Gs
V2Increase water permeability and resorption in collecting ducts of kidney
PCPPhencyclidine
PhencyclidineNMDA R antagonist. Psychosis, agitation, ataxia, nystagmus, delirium.
RodenticidesHave brodifacoum (long acting 4-hydroxycoumarin). Can cause coagulopathy and abnormal bleeding (like warfarin).
Fresh frozen plasma + vitKFor warfarin and rodenticide tx.
memorize
x:x
Question Answer
Leadinhibits ferrocholetase and ALA dehydratase (protoporphyrin to heme)= decrease heme and increased RBC protoporphyrin.
Inhibits rRNA degradation (basophilic stipping)lead
High risk in old houseslead poisoning
Lead poisoning sxlead lines in gingival and metaphases. Encephalopathy. Abdominal colic and sideroblastic anemia
Dimercaprol and EDTA. Succimer for chelation in kidslead poisoning tx
Half life equationt1/2 = 0.7 x Vd/ CL
memorize

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