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Pharmacology book -1-7

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medmaestro's version from 2016-01-19 04:28

Section

PHARMACOLOGY-ANTIMICROBIALS
1.MAJOR ROUTES OF DRUG ELIMINATION
Question Answer
AminoglycosidesRenal
Amphotericin BRenal
Beta lactamsRenal
QuinolonesRenal
SulphonamidesRenal
TetracyclinesRenal
memorize

 

Question Answer
MetronidazoleHepatic/Biliary
ErythromycinHepatic/Biliary
CeftriaxoneHepatic/Biliary
AzithromycinHepatic/Biliary
NovobiocinHepatic/Biliary
LinezolidHepatic/Biliary
IsoniazidHepatic/Biliary
StreptograminsHepatic/Biliary
MoxifloxacinHepatic/Biliary
ClindamycinHepatic/Biliary
CefoperazoneHepatic/Biliary
DoxycyclineHepatic/Biliary
AmpicillinHepatic/Biliary
RifampicinHepatic/Biliary
ChloramphenicolHepatic/Biliary
memorize

 

2.Drugs effective against anaerobic organisms
Cefmetazole
Cefotetan
Cefoxitin
Chloramphenicol
Clindamycin
Metronidazole
Moxifloxacin
Trovafloxacin
Vancomycin
Aminoglycosides are not effective against anaerobic organism .

 

3.Drugs effective against Pseudomonas
Beta Lactam Antibiotics
Question Answer
CarboxypenicillnCarbenicillin, Ticarcillin
UreidopenicillinPiperacillin,Azlocillin , Mezlocillin
CarbapenemsImipenem, Doripenem , Meropenem
MonobactamsAztreonam
CephalosporinsCeftazidime ,Cefoperazone ,Moxalactam, Cefepime , Cefpirome
memorize
OTHER Group of drugs
Question Answer
FluoroquinolonesCiprofloxacin , Pefloxacin,Levofloxacin
Polypeptide antibioticsColistin, Polymixin B
AminoglycosidesGentamycin , Tobramycin,Amikacin etc
memorize
• Vancomycin is NOT active against Pseudomonas
• Ceftazidime plus Aminoglycoside is the treatment of choice for Pseudomonas infections .

 

4.Side effects of Aminoglycosides
EffectMaximumMinimum
NephrotoxicityNeomycin > GentamicinStreptomycin
OtotoxicityAmikacin (Auditory);Streptomycin (Vestibular)Netilmicin
Neuromuscular blockadeNeomycin > StreptomycinTobramycin
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5.PIN Index sysyem in anaesthetic gases
GasPIN IndexColour of cylinder
Air1,5Grey body with white shoulders
O2 2,5Black body with white shoulders
N2O3,5Blue
CO2 (>7.5%)1,6Grey
CO2(<7.5%)2,6Grey
Cyclopropane3,6Orange
Entonox7Blue body with white shoulders
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  6.DRUGS Effective against MRSA (COLDD RST3V)
Cotrimoxazole
Dalbavancin
Daptomycin
Linezolide
Oritavancin
Rifampicin
Streptogramins
Teicoplanin
Telavancin
Tetracyclines
Vancomycin

 

7. Antimicrobials of choice for PROPHYLAXIS
DiseaseDOC For Prophylaxis
AnthraxCiprofloxacin / Doxycycline
CholeraTetracycline/Furazolidone or single dose doxycycline
DiphtheriaPenicillin/Erythromycin
EndocarditisAmoxicillin/Clindamycin
Gonorrhoea/SyphilisProcaine Penicillin
Group B Streptococcal InfectionAmpicillin
Hemophilus Influenza Type BRifampicin
Herpes SimplexAcyclovir
Influenza A & BOseltamivir (>13 Yrs -75mg Od X10days For Post Exposure Prophylaxis Or For 6 Weeks For Community Breaks )
MalariaChloroquine/Mefloquine/Doxycycline
Meningococcal MeningitisRifampicin /Ceftriaxone/Ciprofloxacin(19th Edition Harrison Says - Doc For Prophylaxis Is Ceftriaxone ,Not Rifampicin;Rifampicin Is Used For Meningococcal Carriers )
Mycobacterium Avium Complex (Mac)Azithromycin / Clarithromycin/Rifabutin
Otitis MediaAmoxicillin
PertussisAzithromycin
PlagueTetracycline
Pneumocystis JiroveciCotrimoxazole/Dapsone/Atovaquone
Rheumatic FeverBenzathine Penicillin
Rickettsial InfectionsTetracyclines
Surgical ProphylaxisCefazolin
ToxoplasmosisCotrimoxazole
TuberculosisIsoniazid Alone Or With Rifampicin
Urinary Tract InfectionsCotrimoxazole
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