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Pharmacology 3 (TQ)

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sophiaho's version from 2016-02-10 19:19

Cardiovascular/Pulmonary

Question Answer
coronary vasospasm -3cocaine, sumatriptan, ergot alkaloids (Bromocriptine)
cutaneous flushing - 4vancomycin (infusion rate), adenosine, niacin (PGs), Ca channel blockers
VANC
dilated cardiomyopathy -2doxorubicin, daunorubicin
Double Ds are really big
torsades - 5- Class III (e.g., sotalol)
- class IA (e.g.,quinidine)
- macrolide
- antipsychotics
- TCAs
dry cough - 1ACE inhibitors
pulmonary fibrosis - 4Bleomycin, Amiodarone, Busulfan, Methotrexate
Breathing Air Badly from Medications
tachyphylaxis - 2alpha-agonist nasal decongestants, nitroglycerin
-due to negative feedback that diminish their effects
memorize

Hematologic

Question Answer
Agranulocytosis - 6Ganciclovir, Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, PTU
Gangs and Drugs CCCrush Myeloblasts and Promyelocytes
Aplastic anemia - 6Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, PTU
Can’t Make New Blood Cells Properly
Direct Coombs positive hemolytic anemia - 2methyldopa, penicillin
Gray baby - 1chloramphenicol
hemolysis in G6PD deficient patients - 7INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Hemolysis IS D PAIN
megaloblastic anemia - 3Phenytoin, methotrexate, sulfa drugs (ie TMP)
Having a blast with PMS
thombocytopenia - 2Heparin, cimetidine
thrombotic complications OCPs
memorize

GI

Question Answer
acute cholestatic hepatitis - 1Erythromycin
diarrhea - 5Metformin, Erythromycin, Colchicine, Orlistat, Acarbose
Might Excite Colon On Accident
Focal to massive hepatic necrosis - 4Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen
Liver “HAVAc”
hepatitis - 1INH
hepatotoxicityStatins, Amiodarone
Pancreatitis - 6Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)
Drugs Causing A Violent Abdominal Distress
pseudomembranous colitis - 3Clindamycin, ampicillin, cephalosporins
(Antibiotics predispose to superinfection by resistant C. difficile)
memorize

Endo/Repro

Question Answer
adrenocortical insufficiency - 1HPA suppression 2° to glucocorticoid
withdrawal
*gynecomastia- Spironolactone
- [Dope] marijuana
- Digitalis
- Estrogen
- Cimetidine
- Alcohol
- Heroin
- Dopamine
- D2 antagonists
- Ketoconazole

Some Dope Drugs Easily Create Awkward Hairy DD Knockers

cirrhosis, testicular tumor, etc
hot flashes - 2Tamoxifen, clomiphene
hypothyroidism - 3lithium, amiodarone, sulfonamides
hyperglycemia - 6-Tacrolimus
- Protease inhibitors
- Niacin,
- HCTZ
- β-blockers
- Corticosteroids
Taking Pills Necessitates Having Blood Checked
dyslipidemia - 3Metoprolol, Thiazide, Bile Acid resins
memorize

Musculoskeletal/skin/connective tissue

phenytoin fucks up the connective tissues, same for cyclosporine
Question Answer
fat redistribution - 2glucocorticoids, protease inhibitors
Fat PiG
gingival hyperplasia - 4Phenytoin, verapamil, cyclosporine, nifedipine
gout - 5Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
Painful Tophi'd Feet Need Care
myopathies - 8Fibrates, niacin, statins, glucocorticoids
colchicine, hydroxychloroquine, interferon-α, penicillamine
osteoporisis - 2corticosteroids, heparin
photosensitivity - 4Sulfonamides, Amiodarone, Tetracyclines, 5-FU
Fuck You SAT!
SJS - 4- Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital)
- Allopurinol
- Sulfa drugs
- Penicillin
Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin
SLE - 6Sulfa drugs (thio/sulf), Hydralazine, INH, Procainamide, Phenytoin, Etanercept
Having lupus is “SHIPP-E”
Tendonitis, rupture, cartilage damage - 1fluoroquinolones
Teeth discoloration - 1Tetracyclines teetracylcines
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GI/Renal

cyclophosphamide fcks the kidneys
Question Answer
diabetes insipidus - 2lithium, demeclocycline
Fanconi's syndrome - 1expired tetracycline
interstitial nephritis - 3Methicillin, NSAIDs, furosemide
hemorrhagic cystitis - 2cyclophosphamide, ifosfamide
- Prevent by coadministering with mesna
SIADH - 3Carbamazepine, Cyclophosphamide, SSRIs
Can’t Concentrate Serum Sodium
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Neuro

Question Answer
cinchonism - 2quinidine, quinine
QQ
parkinsons - 3Antipsychotics, reserpine, metoclopramide
Cogwheel rigidity of ARM
seizures - 6INH (vitamin B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol/Theophylline, Enflurane, Metoclopramide
With seizures, I BITE My tongue
tardive dyskenesia - 2Antipsychotics, metoclopramide
memorize

Multiorgan

Question Answer
Antimuscarinic - 4Atropine like drugs, TCAs, H1 -blockers, antipsychotics
3' C (Coma, Convulsion, Cardiotoxicity)
Disulfiram-like reactionMetronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st-generation sulfonylureas
Nephrotoxicity/ototoxicity - 4Aminoglycosides, vancomycin, loop diuretics, cisplatin
memorize

P450

Inducers
Question Answer
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsChronic Alcohol use
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsModafinil
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsSt. John’s wort
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsPhenytoin
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsPhenobarbital
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsNevirapine (AIDS drug)
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsRifampin
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsGriseofulvin
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy CarbsCarbamazepine
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Substrates
Question Answer
Always, Always, Always, Always Think When Starting OthersAnti-epileptics
Always, Always, Always, Always Think When Starting OthersAntidepressants
Always, Always, Always, Always Think When Starting OthersAntipsychotics
Always, Always, Always, Always Think When Starting OthersAnesthetics
Always, Always, Always, Always Think When Starting OthersTheophylline
Always, Always, Always, Always Think When Starting OthersWarfarin
Always, Always, Always, Always Think When Starting OthersStatins
Always, Always, Always, Always Think When Starting OthersOCPs
memorize

 

Inhibitors
Question Answer
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsAcute alcohol abuse
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsGemfibrozil
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsCiprofloxacin
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsIsoniazid
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsQuinidine
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsAmiodarone
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsKetoconazole
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsMacrolides (esp erythromycin)
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsSulfonamides
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsCimetidine
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon RollsRitonavir (protease inhibitors in HIV, the -avir's)
memorize

Sulfa Drugs

Question Answer
Popular FACTSSSProbenecid
Popular FACTSSSFurosemide
Popular FACTSSSAcetazolamide
Popular FACTSSSCelecoxib
Popular FACTSSSThiazides
Popular FACTSSSSulfonamide antibiotics, Sulfasalazine, Sulfonylureas
Sulfa Drug reactions (7)- fever
- urinary tract infection
- Stevens-Johnson syndrome
- hemolytic anemia,
- thrombocytopenia
- agranulocytosis
- urticaria (hives)
Symptoms range from mild to life threatening.
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