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Pharmacokinetics Lecture 3 IV Bolus Modeling, Plasma Curves & Data Analysis. Part I

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alchemist04's version from 2016-07-20 21:52

Section

Question Answer
3 approaches to modeling (1)(1) Compartment analysis
3 approaches to modeling (2)(2) Non Compartment or Statistical moment analysis
3 approaches to modeling (3)(3) Physiologically based analysis
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Question Answer
T or F? Compartment analysis views body as 1 or more compartments which are interconnectedTrue, each compartment behaves the same way w/ regards to a given drug
T or F? Compartment represents real anatomical spacesFalse, In compartment, anatomical space or tissues that behaves the same way are lump together.
T or F? Compartment Analysis ff the 1st order kineticsTrue. As the drug dose increases, so also the The rate of elimination of drug is increased
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Question Answer
What are the assumptions of 1 compartment model? (1)(1) Body is a single (black box), well-mixed container and drug in the body is in rapid equilibration with drug in tissue
What are the assumptions of 1 compartment model? (2)(2) Drug is instantaneously distributed throughout the body
What are the assumptions of 1 compartment model? (3)(3) 1st Order elimination - rate of change of drug concentration (dC/dt) is proportional to drug concentration (C)
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Question Answer
Formula for One Compartment model for IV bolusdX/dt = -kX. If dose (x) is increased, the K is decreased because K is negative slope.
In One Compartment model, if the amount of drug or the dose of drug is doubled, the rate of change of X with time (dX/dt) is also doubled. True or False?True
Phentermine k = 0.028/hr. If Phentermine dose is doubled to 60 mg/day, you'd expect the elimination rate constant (k) to .... (a) double (b) decrease (c) stay the sameAns is DECREASE. Since K = slope, does the slope increase or decrease when dose is doubled?. Remember in Compartment model, the equation is dX/dt = -kX where the negative is an indication of loss of drug.
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Question Answer
T or F? When the concentration of drug is increased, the elimination constant (k) decreasedTrue
T of F? When the concentration of drug is increased, the slope (k) of semilog plot of drug will remain the sameTrue. The k constant of slope which is not the same as K constant of elimination will remain unchanged. The k constant of elimination will decrease.
Formula for Elimination rate constant (k)k = - (slope) = [(Ln C2 - Ln C1)]/[t2-t1] OR k = -2.3(slope) = -2.3 (log C2 - log C1) / [t2 - t1]
T or F? Half-life is a reciprocal/inverse of the elimination rate constantTrue
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Question Answer
Which plot is linear, the curve or the straight line?The curve
Which plot is semilogarithmic plot, the curve or the straight line?The straight line
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