# Pharmacokinetics Lecture 3 IV Bolus Modeling, Plasma Curves & Data Analysis. Part I

rename
alchemist04's
version from
2016-07-20 21:52

## Section

Question | Answer |
---|---|

3 approaches to modeling (1) | (1) Compartment analysis |

3 approaches to modeling (2) | (2) Non Compartment or Statistical moment analysis |

3 approaches to modeling (3) | (3) Physiologically based analysis |

Question | Answer |
---|---|

T or F? Compartment analysis views body as 1 or more compartments which are interconnected | True, each compartment behaves the same way w/ regards to a given drug |

T or F? Compartment represents real anatomical spaces | False, In compartment, anatomical space or tissues that behaves the same way are lump together. |

T or F? Compartment Analysis ff the 1st order kinetics | True. As the drug dose increases, so also the The rate of elimination of drug is increased |

Question | Answer |
---|---|

What are the assumptions of 1 compartment model? (1) | (1) Body is a single (black box), well-mixed container and drug in the body is in rapid equilibration with drug in tissue |

What are the assumptions of 1 compartment model? (2) | (2) Drug is instantaneously distributed throughout the body |

What are the assumptions of 1 compartment model? (3) | (3) 1st Order elimination - rate of change of drug concentration (dC/dt) is proportional to drug concentration (C) |

Question | Answer |
---|---|

Formula for One Compartment model for IV bolus | dX/dt = -kX. If dose (x) is increased, the K is decreased because K is negative slope. |

In One Compartment model, if the amount of drug or the dose of drug is doubled, the rate of change of X with time (dX/dt) is also doubled. True or False? | True |

Phentermine k = 0.028/hr. If Phentermine dose is doubled to 60 mg/day, you'd expect the elimination rate constant (k) to .... (a) double (b) decrease (c) stay the same | Ans is DECREASE. Since K = slope, does the slope increase or decrease when dose is doubled?. Remember in Compartment model, the equation is dX/dt = -kX where the negative is an indication of loss of drug. |

Question | Answer |
---|---|

T or F? When the concentration of drug is increased, the elimination constant (k) decreased | True |

T of F? When the concentration of drug is increased, the slope (k) of semilog plot of drug will remain the same | True. The k constant of slope which is not the same as K constant of elimination will remain unchanged. The k constant of elimination will decrease. |

Formula for Elimination rate constant (k) | k = - (slope) = [(Ln C2 - Ln C1)]/[t2-t1] OR k = -2.3(slope) = -2.3 (log C2 - log C1) / [t2 - t1] |

T or F? Half-life is a reciprocal/inverse of the elimination rate constant | True |

Question | Answer |
---|---|

Which plot is linear, the curve or the straight line? | The curve |

Which plot is semilogarithmic plot, the curve or the straight line? | The straight line |

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