# Pharmacokinetics I Lecture I Part 2

rename
alchemist04's
version from
2016-06-19 21:04

## Section

Question | Answer |
---|---|

T or F? Rate of reaction (process) is the velocity at which it occurs | True |

T or F? In 1st order, there are more metabolizing enzymes than the amount of drug in the body | True |

T of F? In 1st order, there are more drug in the body than the metabolizing enzymes? | False, there are far less drug in the body than the metabolism enzymes. |

What is the formula for 1st order kinetics? | dX/dt = kX |

Question | Answer |
---|---|

Define Order of a reaction | it is the way in which the drug concentration influence the rate of reaction |

Define rate of reaction | it is the velocity at which drug reaction occurs. It is the rate at which drug disappear form the blood plasma as a function of time. |

In 1st order reaction, what happens to the half life of drug when the drug concentration increases? | The half life of the drug remains unchanged |

IN Zero order reaction, what happens to the half life of drug when drug concentration increases? | The half life changes, it increases. |

Question | Answer |
---|---|

In 1st order, when X increases, what happens to the rate of formation of X(dX/dt)? | the formation of increases as the amount of X increases. |

T or F? In 1st order, the rate of reaction is dependent of the amount/level of X | True |

T or F? The rate of appearance of X(dX/dt) is proportional to the amount of X present | True |

What happens to 1st order when an excessive dose of drug is given (range in MTC)? | there is more drug molecules than the metabolizing enzyme. Hence, there is a zero order (I.e. no Zero order is observed here) |

What is an example of drug that follows zero order? | Phenytoin |

Question | Answer |
---|---|

What is the consequence of Zero-order? | the half-life changes with dose. |

In Zero order kinetics, when X increase, what happens to rate of reaction (formation or appearance)? | the rate of reaction does not change. |

T or F? In Zero order, the rate of reaction is not independent of the level of X | False, It is independent of X |

T or F? Zero order is described by the rate constant alone | True |

T or F? Zero order = K[X]^0 where [X]^0 = 1 and K * 1 = K | True. in Zero order, the K constant is independent of X because X is raised to power zero. Hence, it will not have any effect on K |

What is the formula for Zero order reaction? | K = dX/dt |

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