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Pharmacokinetics I Lecture I Part 2

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alchemist04's version from 2016-06-19 21:04

Section

Question Answer
T or F? Rate of reaction (process) is the velocity at which it occursTrue
T or F? In 1st order, there are more metabolizing enzymes than the amount of drug in the bodyTrue
T of F? In 1st order, there are more drug in the body than the metabolizing enzymes?False, there are far less drug in the body than the metabolism enzymes.
What is the formula for 1st order kinetics?dX/dt = kX
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Question Answer
Define Order of a reactionit is the way in which the drug concentration influence the rate of reaction
Define rate of reactionit is the velocity at which drug reaction occurs. It is the rate at which drug disappear form the blood plasma as a function of time.
In 1st order reaction, what happens to the half life of drug when the drug concentration increases?The half life of the drug remains unchanged
IN Zero order reaction, what happens to the half life of drug when drug concentration increases?The half life changes, it increases.
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Question Answer
In 1st order, when X increases, what happens to the rate of formation of X(dX/dt)?the formation of increases as the amount of X increases.
T or F? In 1st order, the rate of reaction is dependent of the amount/level of XTrue
T or F? The rate of appearance of X(dX/dt) is proportional to the amount of X presentTrue
What happens to 1st order when an excessive dose of drug is given (range in MTC)?there is more drug molecules than the metabolizing enzyme. Hence, there is a zero order (I.e. no Zero order is observed here)
What is an example of drug that follows zero order?Phenytoin
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Question Answer
What is the consequence of Zero-order?the half-life changes with dose.
In Zero order kinetics, when X increase, what happens to rate of reaction (formation or appearance)?the rate of reaction does not change.
T or F? In Zero order, the rate of reaction is not independent of the level of XFalse, It is independent of X
T or F? Zero order is described by the rate constant aloneTrue
T or F? Zero order = K[X]^0 where [X]^0 = 1 and K * 1 = KTrue. in Zero order, the K constant is independent of X because X is raised to power zero. Hence, it will not have any effect on K
What is the formula for Zero order reaction?K = dX/dt
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