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Pharmacokinetics I Lecture I Part 1

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alchemist04's version from 2016-06-18 01:12

Section

Question Answer
What are the assumptions of Pharmacokinetics? (1)(1) The effectiveness of the therapy is dependent on the amount of drug in the body
What are the assumptions of Pharmacokinetics? (2)(2) Drug concentration in accessible fluid (i.e. Plasma) are in equilibrium with those at the site of action, therefore changes in plasma drug concentration reflect changes in drug concentration at the site of action.
What are the assumptions of Pharmacokinetics? (3)(3) By measuring Plasma concentration of drug, we are measuring the effectiveness of drug therapy.
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Question Answer
What are the assumptions of Drug Plasma Levels (1)(1) That tissue drug concentration, including the concentration at the site of action, is related to the plasma concentration of the drug
What are the assumptions of Drug Plasma Levels (2)(2) Correlate pharmacologic effect with plasma concentration
What are the assumptions of Drug Plasma Levels (3)(3) provide link between Pharmacokinetics and Pharmacodynamics
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Question Answer
Pharmacokinetics predicts ---------------?plasma drug levels at anytime after drug administration (i.e. during Absorption, distribution, metabolism, Elimination)
Pharmacokinetics factors are ----------?(1) %concentration (Y axis) (2) Time in min or secs (X axis)
Pharmacodynamics goal is to predict --------?the intensity of drug's effect as a function of effects and concentration
Pharmacodynamics factors are ---------?(1) % effect (Y axis) and (2) Log of Concentration (X axis)
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Question Answer
What is the link between PK monitoring (i.e. therapeutic drug monitoring)? (1)(1) drug effectiveness must be linked to amount of drug in the body (plasma)
What is the link between PK monitoring (i.e. therapeutic drug monitoring)? (2)(2) Drug concentration in plasma reflects drug concentration at the site of action
What is the link between PK monitoring (i.e. therapeutic drug monitoring)? (3)(3) Measuring drug plasma concentration = measuring effectiveness of drug therapy
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Question Answer
When Plasma concentration are not predictive of clinical response or physiological response/changes or pharmacologic response to therapeutic interventions, how do you measure pharmacodynamics?Use Biomarkers
What are the examples of Biomarkers? (1)(1) Prothrombin for Warfarin
What are the examples of Biomarkers? (2)(2) Electrophysiology (ECG changes) for digoxin therapy
What are the examples of Biomarkers? (3)(3) Blood glucose and/or HbA1c for anti-hyperglycemic therapy
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Question Answer
A patient takes Ciprofloxacin with Olanzapine, a drug used to treat Schizophrenia. Cipro (inhibitor substrate) blocks the enzyme that breaks down Olanzapine; is this Pharmacodynamic or pharmacokinetics?Pharmacokinetics (involves changes in the rate of absorption/metabolism)
A patient takes Ciprofloxacin with Olanzapine, a drug used to treat Schizophrenia. Cipro (inhibitor substrate) blocks the enzyme that breaks down Olanzapine; what will be the resulting effects?the result will be unmetabolized Olanzapine, increase blood concentration level of Olazanpine and cause muscle spasms + predispose patient to falls.
A patient takes Cipro w/ Glibenclamide (antidibetic), the result is increase in antidiabetic effect of glibenclamide, causing profound hypogycemia. Is this Pharmacodynamic or pharmacokinetics?Pharmacodynamics bc it is drug dose response
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