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Pharmacogenomics

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zahezado's version from 2015-04-30 18:02

Section 1

Question Answer
2C9*1Extensive
2C9*2Intermediate
2C9*3Poor
2C9*6Poor
2C19*1Extensive
2C19*2Poor
2C19*3Poor
2C19*17Ultra rapid
2D6*1Extensive
2D6*2Extensive
2D6*2xNUltra rapid
2D6*3Poor
2D6*4Poor
2D6*5Poor
2D6*10Poor
2D6*17Poor
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Section 2

Question Answer
UGT1A1*8Poor
NAT2*4Extensive
NAT2*5Poor
NAT2*6Poor
NAT2*7Poor
SLCO1B1*1A/1BIncreased hepatic uptake
SLCO1B1*5Decreased hepatic uptake
SLCO1B1*15Decreased hepatic uptake
SLCO1B1*17Decreased hepatic uptake
VKORC1*1Normal
VKORC1*2Reduced activity
VKORC1*3Increased activity
ADRB1*1Normal receptor sensitivity
ADRB1 389Decreased receptor sensitivity
ADRB1 49Increased receptor sensitivity
ADRB2*1Normal receptor sensitivity
ADRB2 16Decreased receptor senstivity
ADRB2 27Increased receptor sensitivity
HMGCR Snp 12Decrease statin effectiveness
HNGCR Snp 29Decrease statin effectiveness
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Section 3

Question Answer
HLA-B*5701Abacavir
HLA-B*5801Allopurinol
HLA-B*1502Carbamazepine, phenytoin
G6PDRasburicase, primaquine, sulfonylureas, dapsone
2C9Warfarin, phenytoin, NSAIDs, sulfonylureas
2C19Clopidogrel, diazepam, TCA, PPI
2D6TCAs, SSRIs, antipsychotics, tramadol, codeine, hydrocodone, oxycodone, beta blockers, antiarrhythmics, tamoxifen, dextromethorphan
UGT1A1Irinotecan
NAT2Isoniazid, hydralazine, sulfasalazine
ABCB1digoxin, statins, cyclosporine/tacrolimus, protease inhibitors, rifampin
SLCO1B1Simvastatin
VKORWarfarin
ADRB1beta blockers
ADRB2beta blockers
HMGCRStatins
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