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Pharmaceutics III wk 6 lecture 9 Tablets and Coated Tablets Part 2

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alchemist04's version from 2016-05-19 03:13

Section

Question Answer
What are the characteristics of Chewable tablets (1)(1) Primary rational is to get drug into the blood stream as quickly as possible
What are the characteristics of Chewable tablets (2)(2) Low compression to yield minimum hardness
What are the characteristics of Chewable tablets (3)(3) Nonhygroscopic made of alcohol granules ensure that the does not collect water
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Question Answer
What are the characteristics of Chewable tablets (4)(4) Mannitol is the major excipient, more than 50%
What are the characteristics of Chewable tablets (5)(5) Mannitol conveys good taste and disintegration
What are the characteristics of Chewable tablets (6)(6) Add colorant, tart or fruit flavorant to increase compliance
What are the characteristics of Chewable tablets (7)(7) Chewable tablets disintegrate smoothly w/ or w/o chewing and produce smooth, even texture
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Question Answer
What are the characteristics of Rapidly Dissolving tablets (1)(1) Primary rational is to get drug into the bloodstream as quickly as possible
What are the characteristics of Rapidly Dissolving tablets (2)(2) Manufactured by low force compression of large volume or by Lyophilization
What are the characteristics of Rapidly Dissolving tablets (3)(3) Friable and require individual protective package
What are the characteristics of Rapidly Dissolving tablets (4)(4) Dissolve in mouth, no need to swallow
What are the characteristics of Rapidly Dissolving tablets (5)(5) example is drug for nausea
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Question Answer
What is the characteristic of effervescent?Gives CO2 bubbles when come in contact with water
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Question Answer
What are the advantages of coated tablets (1)(1) Goal is not to allow acid drug to come in contact with gastric acid
What are the advantages of coated tablets (2)(2) Easier to dispense
What are the advantages of coated tablets (3)(3) Easier to swallow
What are the advantages of coated tablets (4)(4) Taste better (sugar coated)
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Question Answer
What are the advantages of coated tablets (5)(5) Less friable (many layers)
What are the advantages of coated tablets (6)(6) drug content is protected from moisture or gastric contents (coat protect drug)
What are the advantages of coated tablets (7)(7) Can modify tablet disintegration or dissolution time (SR)
What are the advantages of coated tablets (8)(8) allow each drug to be ID by strength (imprint on each dose)
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Question Answer
Disadvantages of Coated tablets are (1)(1) Tougher to manufacture, add complexity to tablet manufacturing
Disadvantages of Coated tablets are (2)(2) can modify tablet disintegration/solution behavior
Disadvantages of Coated tablets are (3)(3) cannot be used for fast onset drug product, because it contains layers of contents
Disadvantages of Coated tablets are (4)(4) can decrease drug stability by introducing too much moisture into the tablets during manufacturing
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Question Answer
What are the merits of film coated tablets (1)(1) Dissolve more slowly than those with sugar coating
What are the merits of film coated tablets (2)(2) More durable (less friable) than coating
What are the merits of film coated tablets (3)(3) More abrasion resistant than sugar coating
What are the merits of film coated tablets (4)(4) Decreased manufacturing time compare to sugar coating
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Question Answer
Advantages of Enteric film coated tablets (1)(1) The most important of film coating
Advantages of Enteric film coated tablets (2)(2) Employed by drugs which are decomposed by stomach acid, in order to get them into the small intestine
Advantages of Enteric film coated tablets (3)(3) Protects acid sensitivity drugs from the acidic contents of the stomach
Advantages of Enteric film coated tablets (4)(4) Protects stomach lining from irritating drugs
Advantages of Enteric film coated tablets (5)(5) Multiple coating to resist dissolution in the stomach
Advantages of Enteric film coated tablets (6)(6) Dissolve once environment reaches pH 4.8
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Question Answer
Examples of Enteric coating polymers are (1)(1) Shellac
Examples of Enteric coating polymers are (2)(2) Polyvinyl acetate phthalate
Examples of Enteric coating polymers are (3)(3) Hydroxypropylmethyl cellulose phthalate
Examples of Enteric coating polymers are (4)(4) Cellulose acetate phthalate
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