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Pharmaceutics III wk 6 lecture 9 Tablets and Coated Tablets Part 1

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alchemist04's version from 2016-05-19 01:50

Section

Question Answer
What are the advantages of tablets as a dosage form? (1)Good drug stability
What are the advantages of tablets as a dosage form? (2)High dose accuracy
What are the advantages of tablets as a dosage form? (3)Low cost of manufacture
What are the advantages of tablets as a dosage form? (4)Patient convenience
What are the advantages of tablets as a dosage form? (5)Ability to control timing and duration of drug release into the body
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Question Answer
What are the qualities to be expected from tablets as a dosage form? (1)Correct dose
What are the qualities to be expected from tablets as a dosage form? (2)Limited impurities
What are the qualities to be expected from tablets as a dosage form? (3)Correct disintegration and drug release rate
What are the qualities to be expected from tablets as a dosage form? (4)Homogeneity
What are the qualities to be expected from tablets as a dosage form? (5)Limited friability
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Question Answer
What are the examples of uncoated tablets? (1)(1) Immediate release tabs
What are the examples of uncoated tablets? (2)(2) Chewable tabs
What are the examples of uncoated tablets? (3)(3) Rapid dissolving tab
What are the examples of uncoated tablets? (4)(4) effervescent tab
What are the examples of uncoated tablets? (5)(5) regular tab
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Question Answer
What are the excipients/formulation ingredients found in tablets?(1) Filler (2) Binder (3) Disintegrant (3) Lubricants (4) Glidant
Some facts about Filler (1)(1) Largest components of tablets
Some facts about Filler (2)(2) Used primarily to dilute potent drug to allow convenient tablet weight
Some facts about Filler (3)(3) Chemically inert
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Question Answer
Some facts about Binder (1)(1) use to hold drug particles + the filler mixture together
Some facts about Binder (2)(2) they are typically soluble in water if tablet contains non-ionized drug (inactive form)
Some facts about Binder (3)(3) They are soluble in alcohol or acetone if tablet contains the salt form of a drug
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Question Answer
What are the examples of binders? (1)(1) Carboxymethylcellulose sodium
What are the examples of binders? (2)(2) Compressed sugar
What are the examples of binders? (3)(3) Ethylcellulose
What are the examples of binders? (4)(4) Gelatin
What are the examples of binders? (5)(5) Liquid glucose
What are the examples of binders? (6)(6) Methylcellulose
What are the examples of binders? (7)(7) Povidone (Polyvinyl pyrrolidone, PVP)
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Question Answer
What are the examples of disintegrant? (1)(1) Starch
What are the examples of disintegrant? (2)(2) Sodium starch glycollate
What are the examples of disintegrant? (3)(3) Croscarmellose
What are the examples of disintegrant? (4)(4) Microcrystalline cellulose
What are the examples of disintegrant? (5)(5) Sodium
What are the examples of disintegrant? (6)(6) Calcium
What are the examples of disintegrant? (7)(7) Carboxymethicellulose
What are the examples of disintegrant? (8)(8) Crospovidone
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Question Answer
What are the uses of disintegrants? (1)(1) Ensures that drug breaks and disintegrate
What are the uses of disintegrants? (2)(2) Absorbs water and swell to a large volume
What are the uses of disintegrants? (3)(3) Breaks compressed tablets matrix apart and thereby allow more rapid contact btw drug and stomach content (e.g. water) w/n minutes
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Question Answer
What are the examples of lubricant? (1)(1) Calcium and Magnesium stearate
What are the examples of lubricant? (2)(2) Stearic acid
What is the use of lubricant?Keep formed tablets from sticking to dies and molds
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Question Answer
What are the examples of Glidants?(1) Silicon dioxide (fumed) (2) Talc
What are the use of Glidants? (1)(1) Prevent agglomeration (2) Keep powder/granules from clumping as mold is being filled.
What are the disadvantages faced in compression of tablets? (1)(1) Homogeneity problems would result in segregation of different particles in bulk power
What are the disadvantages faced in compression of tablets? (2)(2) Sticking of bulk powder
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Question Answer
What are the characteristics of IR tablets? (1)(1) contain high levels of disintegrant (the more disintegrant the easier and quicker the drug disintegrates)
What are the characteristics of IR tablets? (2)(2) Results in drug being completely exposure to gastric fluid w/n a few minutes
What are the characteristics of IR tablets? (3)(3) Employ salts of drug
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