Create
Learn
Share

Pharmaceutics III lecture 8 Capsules.

rename
alchemist04's version from 2016-06-06 04:09

Section

Question Answer
Advantages of capsules and tablets (aka Oral Dosing)? (1)Drug most stable in solid state
Advantages of capsules and tablets (aka Oral Dosing)? (2)Most convenient dosing technique
Advantages of capsules and tablets (aka Oral Dosing)? (3)Greatest patient acceptability (no pain, no embarrassment)
Advantages of capsules and tablets (aka Oral Dosing)? (4)Most accurate dosing (no patient measurement required)
memorize

 

Question Answer
Why capsules? (1)ease of commercial manufacturer (of shells) and utility in pharmacy compounding
Why capsules? (2)readily prepared in compounding pharmacy when a required dosage strength is not commercially available as tablet.
Why capsules? (3)preferred oral dosage form if the drug is chemically stable, rapidly onset is required, and prolonged duration of effect is not required.
memorize

 

Question Answer
Use of capsules? (1)are intended to be swallowed or (less often) the capsule is opened and the contents sprinkled and mixed on food, or dissolved in a suitable solvent
Use of capsules? (2)employed to store unit of powder in commercial pulmonary inhalation products
memorize

 

Question Answer
Disadv. of capsules? (1)Readily pick up moisture and transmit it to internal contents
Disadv. of capsules? (2)Can stick together and/or drug can decompose
Disadv. of capsules? (3)Difficult to achieve either immediate or sustained drug release (if therapeutically indicated)
memorize

 

Question Answer
What are the compositions of hard gelatin?(1) Sugar (2) water (3) colorants (4) Opacifiers (TiO2)
True or False? Hard gelatin is soluble in cold water, forms gel and softenFalse, hard gelatin is INSOLUBLE in water but forms gel and soften
True of False? Hard gelatin is insoluble in hot water and warm gastric fluidFalse, hard gelatin is SOLUBLE in hot water and warm gastric fluid.
memorize

 

Question Answer
What can you mix in the capsule during capsule formulation?(1) drug powder (2) granules (3) pelletized materials.
Drugs powder are almost always diluted with excipient, primarily to ....?Make administration of very small doses more accurate and convenient
Why is potent drug diluted into the excipient powder or granules prior to filling?To assure accurate dispensing of desired dose
Why is it necessary to fill capsule with uniform powder or granules particle size?to assure proper dose per capsule
memorize

 

Question Answer
For a drug dose/capsule > 10 mg, what should happen to drug and excipient?make sure drug and excipient are fine powders of equivalent size
For a drug dose/capsule < 10 mg, what should you do before mixing?Micronize drug particles to 1-20 micrometer size before mixing with excipient
Why is it necessary to made excipient and drug powder into fine powders when the drug/dose capsule is greater than 10 mg?to assure homogeneity of mixture and reproducibility of dose, capsule to capsule.
Why do you need to micronized drug particles and excipients for dose/capsule of > 10mg?Because it reduces the possibility that contents of a given capsule might be sub-potent or super-potent
Highly potent drugs that are dosed using capsules or tablets are milled to a very fine powder in order to...?Allow uniform and homogeneous dispersion of a drug substance into a large amount of excipient
memorize

 

Question Answer
True of False? Drug powder + excipient formulation does not necessarily need to disperse and /or dissolve quickly?False, formulation needs to dissolve and dispersed quickly
True or False? Drug formulation could be employed to hinder GI absorption of drug?False, Formulation shd not inder GI absorption
True or false? Excipient employed does not need to bind the particular drug?True, Excipient employed should not bind a particular drug
True of false? Drug formulation should be easy to fill into capsule?True
True of false? Fill volume errors can occur if granulation is too largeTrue
True or False? Soft capsule water miscible organic liquids wok best with drug saltTrue
memorize

 

Question Answer
What are the characteristics of capsule formulation? (1)Formulation should dispersed and/or dissolve quickly
What are the characteristics of capsule formulation? (2)Formulation should not hinder GI absorption
What are the characteristics of capsule formulation? (3)Formulation should be easy to fill into capsules
What are the characteristics of capsule formulation? (4)Excipient employed should not bind a particular drug
memorize

 

Question Answer
What are the best ways to store capsules? (1)Package hard gelatin in tightly sealed glass or plastic
What are the best ways to store capsules? (2)Can be packaged with dessicant to prevent moisture absorption
What are the best ways to store capsules? (3)soft gelatin capsule should be stored in a cool, dry environment
What are the best ways to store capsules? (4)for moisture sensitive drugs, package INDIVIDUAL capsules in foil blister packs
memorize

 

Question Answer
What are the advantages of Soft Gelatin Capsules? (1)Easier to swallow (it is pre-lubricated)
What are the advantages of Soft Gelatin Capsules? (2)Can be used to administer a precise volume of viscous liquid formulation
What are the advantages of Soft Gelatin Capsules? (3)Can be used to deliver drug solution
What are the advantages of Soft Gelatin Capsules? (4)Can be used to deliver drug suspension
Drugs administerd using soft gelatin capsules are typically present as ...?(1) Solution (2) Suspension
memorize

 

Question Answer
What are the compositions of soft gelatin capsule? (1)Glycerine or Sorbitol (plasticizer)
What are the compositions of soft gelatin capsule? (2)Water miscible organic liquids like (1) glycerol (2) Propylene Glycol [PG] (3) PEG 400
What are the compositions of soft gelatin capsule? (3)Water immiscible liquid like (1) Vegetable oil or mineral oil (2) Liquid wax
What are the compositions of soft gelatin capsule? (1)
memorize

 

Question Answer
What are the characteristics of capsule product manufacturing? (1)need to translate powder weight to capsule volume
What are the characteristics of capsule product manufacturing? (2)preparation of individual capsule (and tablet) dose by measuring out a volume
What are the characteristics of capsule product manufacturing? (3)amount in each capsule depends on powder density and particles size
What are the characteristics of capsule product manufacturing? (4)Fill errors can occur if granulation is too large
What are the characteristics of capsule product manufacturing? (5)capsule drug dose is controlled by fill weight, which is controlled by fill volume
memorize

 

Question Answer
What are the common diluent excipients used in capsules (1)?Cheap
What are the common diluent excipients used in capsules (2)?Calcium Carbonate
What are the common diluent excipients used in capsules (3)?Chemical and biological inert
What are the common diluent excipients used in capsules (4)?Lactose
What are the common diluent excipients used in capsules (5)?Freeflowing (e.g Glidant like SiO2 (< 1% makes powder free flowing)
What are the common diluent excipients used in capsules (6)?Microcrystalline cellulose
memorize