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Pharmaceutics III Lecture 6 Suspensions Part 3

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alchemist04's version from 2016-04-23 03:54

Section

Question Answer
Suspension stability could be resolved by? (1)by formulation of flocculation of the suspended drug particles
Suspension stability could be resolved by? (2)by making drug particles extremely small
Suspension stability could be resolved by? (3)by having vehicle viscosity to exactly match solid drug density
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Question Answer
In suspension stability change in particle size could cause? (1)if large, could cause rapid settling
In suspension stability change in particle size could cause? (2)if large, reduction of dosing accuracy
In suspension stability change in particle size could cause? (3)if large, reduction in dissolution rate in vivo
In suspension stability change in particle size could cause? (4)if large, potentially reduce drug bioavailability
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Question Answer
In suspension stability drug that forms crystal could cause?drug insolubility and reduction of bioavailability.
What other factors could affect suspension stability?(1) pH variations (2) Storage (3) Refrigeration (4) temperature variation
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Question Answer
What are the disadvantages of drug suspension product? (1)decrease in dosing accuracy overtime due to more rapid settling
What are the disadvantages of drug suspension product? (2)Decreased eye product comfort,and increased fine needle injection problems overtime
What are the disadvantages of drug suspension product? (3)Dispensing volume accuracy issues due to high vehicle viscosity
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Question Answer
Suspension stability problem difficulty to solve through formulation efforts include? (1)Increase in drug particle size
Suspension stability problem difficulty to solve through formulation efforts include? (2)change in drug crystal form (polymorphic transformation)
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Question Answer
How to minimize suspension instability? (1)use most insoluble drug
How to minimize suspension instability? (2)prepare suspension immediately prior to dispensing
How to minimize suspension instability? (3)avoid temperature variations
How to minimize suspension instability? (4)use by a given date (duration of treatment)
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