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Pharmaceutics III Lecture 6 Suspensions Part 2

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alchemist04's version from 2016-04-25 17:08

Section

Question Answer
What are the components of Suspensions?(1) Drug substance (2) Drug vehicles (3) Thickeners (4) Wetting agents
What is the role of thickeners in suspensions? (1)provide the fluid viscosity to slow sedimentation rate.
What is the role of thickeners in suspensions? (2)provide expended structure to disperse the drug particles
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Question Answer
Examples of polymers employed as thickeners? (1)carboxymethylcellulose
Examples of polymers employed as thickeners? (2)Methylcellulose
Examples of polymers employed as thickeners? (3)Xanthang gum
Examples of polymers employed as thickeners? (4)Bentonite
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Question Answer
What is the use of Wetting agents?prevent hydrophobic drug from clumping when they come in contact with water
Examples of Wetting agents (1)Alcohol
Examples of Wetting agents (2)glycerine
Examples of Wetting agents (3)Propylene glycol
Examples of Wetting agents (4)Surfactant
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Question Answer
Sedimentation rate isHow fast the drug particles settle at the bottom of its container
When particle size is reduced what happens to the settling?Settling slow down
When particle size is reduced what happen to the dissolution rate?Dissolution rate increases in-vivo
When particles size is reduced, what happen to the bioavailability of the drug?the bioavailability is increased
When drug particles are reduced to too fined particles, what would be the resulting effect?the fine particles attract each other and cake
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Question Answer
Increase in drug particle diameter will cause an increase in suspension stability or increase in settling rate?Increase in settling rate
Increase in drug substance density will cause a decrease in suspension stability or decrease in settling rate?Decrease in suspension stability
Increase in suspending vehicle viscosity will cause increase in settling or decrease in settling rate?Decrease in settling rate
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Question Answer
Flocculation is the same as?when many particles occupy suspension space to the extent that there is no space for the particles to move or settle to the bottom of the container.
Dosing accuracy of oral suspension can be improved by (1)Milling drug particles into fine dispersion
Dosing accuracy of oral suspension can be improved by (2)Limiting maximum viscosity
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Question Answer
What are the properties of a Gel? (1)Drug presented as suspended particles and immobilized
What are the properties of a Gel? (2)Gel provide viscosity to suspending vehicle
What are the properties of a Gel? (3)Gel help structure drug suspension to achieve flocculation
What are the properties of a Gel? (4)Gel is prepared using water soluble polymers
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