Create
Learn
Share

Pharmaceutics III Lecture 6 Suspensions Part 1

rename
alchemist04's version from 2016-04-23 02:16

Section

Question Answer
What are the advantages of suspension? (1)Low solubility in aqueous solution
What are the advantages of suspension? (2)Greater chemical stability
What are the advantages of suspension? (3)Greater total dose per unit
What are the advantages of suspension? (4)Reduce bitter taste, solid state taste less bitter than liquid
memorize

 

Question Answer
What are the Vehicles to suspensions? (1)Water
What are the vehicles for suspensions? (2)Triglyceride oil
memorize

 

Question Answer
Reasons for oral suspensions (1)Ease of swallowing
Reasons for oral suspensions (2)Preference choice for children and elderly
Reasons for oral suspensions (3)Dosage titration over a range of administration volume
Reasons for oral suspensions (4)Drug is too large as a dosing volume, hence suspension reduces the liquid volume
Reasons for oral suspensions (5)Drug is too insoluble to be administered as a solution
Reasons for oral suspensions (6)Drug is too unstable when in solution but stable in suspension
Reasons for oral suspensions (7)Drug has disagreeable taste
memorize

 

Question Answer
What are the factors that enables drug suspension in a vehicle? (1)Drug is insoluble in the vehicle solution
What are the factors that enables drug suspension in a vehicle? (2)Drug is hydrophobic
What are the factors that enables drug suspension in a vehicle? (3)Drug lacks charges
What are the factors that enables drug suspension in a vehicle? (4)Reduce particle size (micronized)
memorize

 

Question Answer
What would you do to a drug that is water soluble to make it insoluble or in suspension? (1)Change ionization
What would you do to a drug that is water soluble to make it insoluble or in suspension? (2)Change salt form
What would you do to a drug that is water soluble to make it insoluble or in suspension? (3)Change the pH to a value where the drug is non ionizable
What would you do to a drug that is water soluble to make it insoluble or in suspension? (4)change the counterion to form an insoluble salt
memorize

 

Question Answer
A drug substance of tobramycin sulfate is used in suspension. You discovered that it soluble in aqueous solution, what would you do to make it insoluble?Use tobramycin pamoate instead of tobramycin sulfate. Tobramycin pamoate is hydophobic
memorize

 

Question Answer
What are the features of dispersed phase? (1)Coarse particles. For suspension and emulsion, particle size shd be 10-50 microns
What are the features of dispersed phase? (2)Micronized particles
What are the features of dispersed phase? (3)Fine particles (dispersion)
memorize

 

Question Answer
Ophthalmic suspensions must contain? (1)0.9% sodium chloride, for isotonicity
Ophthalmic suspensions must contain? (2)very fine drug particles to reduce patient discomfort
Ophthalmic suspensions must contain? (3)high fluid viscosity
memorize

 

Question Answer
Ophthalmic solution must have fine particles to enhance what? (1)retention
Ophthalmic solution must have fine particles to increase what?local bioavailability
memorize