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Pharmaceutics III Lecture 5 Oral Solution, Syrups, Elixers and Tinctures

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alchemist04's version from 2016-04-20 21:20

Section

Question Answer
What are the Oral solutions used for drug dosing? (1)Easiest of all dosage forms to prepare
What are the Oral solutions used for drug dosing? (2)Easiest of all dosage forms to administer
What are the Oral solutions used for drug dosing? (3)Drug dissolution in the GI tract not an issue
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Question Answer
Why are oral solutions used for drug dosing? (1)Allow treatment of patients unable to swallow tablets
Why are oral solutions used for drug dosing? (2)Allow oral therapy where desired dose is not available as a commercial tablet (preparation by compounding pharmacist)
Why are oral solutions used for drug dosing? (3)Easy dose adjustment is possible
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Question Answer
What are the problems or disadvantages of oral solutions? (1)Solution may contain organic solvents
What are the problems or disadvantages of oral solutions? (2)Possible dosing problems (will need a graduating dosing device for a patient, especially uneducated ones)
What are the problems or disadvantages of oral solutions? (3)Limited palatability (most dissolved drugs are bitter)
What are the problems or disadvantages of oral solutions? (4)Dissolved drug stability issues (in certain instance like compounding, shelf life is measured in days.
What are the problems or disadvantages of oral solutions? (5)Limited drug solubility which may require (a) high dosing volume (b) excessive amount of organic co-solvent
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Question Answer
Free acid/base drugs much more soluble in?alcohol than water
Salts of acid/base drugs much more soluble in?water than alcohol
What are the disadvantages of liquid oral drug formulation?(1) bad palatability (2) not easy to buffer (3) pH not easy to control (4) low dosage accuracy unless you use syringes or measuring tool
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