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Pharmaceutics III Lecture 2

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alchemist04's version from 2016-04-11 17:37

Section

Question Answer
Maximum tolerated concentrationis a drug blood level where side effects and adverse effects become more common
Minimum effective concentrationIs a level of drug in the blood where, on the average, acceptable therapeutic response is achieved.
Which one would possibly occur under IV, MTC or MEC?MTC
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Question Answer
What are the advantages of IV drug administration?Ability to administer large volume of fluid and large drug dose. 2) very rapid onset 3) complete availability of administered dose
What is the relationship btw AUC and bioavailability as related to safety, efficacy, MTC and MEC when comparing enteral and parenteral dosing1) AUC is area under the curve, the apex which is Cmax is reached faster with perenteral than enteral.
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Question Answer
What are the difference btw IV bolus, Intermittent IV infusion and Continuous IV infusion, Graphically?Give examples: IV bolus has the fastest onset and the highest Cmax with the shortest Tmax (duration) while the Intermittent infusion has low and varying Cmax with continuing Tmax (duration). The continuous infusion has a plauteu Cmax which extend continuosly (flat out) to a period of Tmax
If a drug is formulated below pH < 4, what will be the side effect?Tissue damage, necrosis, protein precipitation
If a drug is formulated above pH >9, what will be the side effect?Tissue damage, necrosis, protein precipitation
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Question Answer
A drug is considered to be oleaginous solution, what will be the best route of administration?Intramuscular route
An injection of 2.5 mL is to be delivered to a patient, what will be the best parenteral route to deliver this medication?Intra Muscular route (0.5 ml - 3.0 mL)
You have a drug that targets lymph node, what parenteral route will be the best to deliver this drug?Subcutaneous route. A portion of injected node is transported to the lymphatic node
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Question Answer
What is the best parenteral route to deliver an drug volume of < 1.5 mL?SC route
A drug is formulated as emulsion, what will be the best parenteral route to deliver the drug?SC, IM (definitely not IV route)
How is SC and IM dosing different from IV dosing?IV dosing is large and can only be in a solution form while SC/IM are small dosing and can be in any form (Solution, Suspension or Emulsion)
Which one of this is used to dose recombinant proteins? IM, SC, IDSC
Which of the ff dosing has similar bioavailability and what is the bioavailability?SC and IM, close to 100%
A drug has a small volume of btw 0.01-0.1 mL and needed to be apply into the superficial layer of the skin, what type of route would you use?Intradermal (ID)
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Question Answer
In an IV sets, what part would you use for adding medication to the IV?Y-site
Y-site is used for?adding medication to the IV
Which External Infusion Pump is used for continuous pain management, diabetic, TPN, IV antibiotics?Ambulatory Pumps
Which External Infusion Pump is used for delivery analgesic to a patient?PCA Pump
Which External Infusion Pump is mostly used for long-term injection of small volumes of solutions where great accuracy is required (e.g. Neonatal care)Syringe Pumps
The greatest potential problem encountered during drug dosing with IV sets is?Adsorption to surfaces of the IV container
The fastest way to deliver injection into the blood is?SC and IM
The best was to achieve immediate onset of drug action is by?IV bolus injection
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