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Pharmaceutics III Lecture 10 Part 1

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alchemist04's version from 2016-06-04 04:51

Section

Question Answer
How can you modify drug to get improved therapeutic effects (1)(1) Modify chemical composition
How can you modify drug to get improved therapeutic effects (2)(2) Modify delivery dosage form
How can you modify drug to get improved therapeutic effects (3)(3) Modify drug regiment or frequency
How can you modify drug to get improved therapeutic effects (4)(4) Modify route of delivery
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Question Answer
What are the reasons for drug modification (1)(1) Unique therapeutic needs
What are the reasons for drug modification (2)(2) Market desires
What are the reasons for drug modification (3)(3) Route of administration requirements for a particular patient type
What are the reasons for drug modification (4)(4) to address biopharmaceutics need
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Question Answer
What are the factors affecting Biopharmaceutics need (1)(1) Route of administration
What are the factors affecting Biopharmaceutics need (2)(2) Drug physiochemical properties
What are the factors affecting Biopharmaceutics need (3)(3) Patients age
What are the factors affecting Biopharmaceutics need (4)(4) Patients sex and race
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Question Answer
T or F? Drug toxicity affects biopharmaceutics of a drugFalse
T or F? Biopharmaceutics is the interactions between drug and body independent of pharmacologic activityTrue
T or F? Biopharmaceutics is the interaction drug and body influenced by drug molecular structure and physiochemical propertiesTrue
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Question Answer
LADMER meansLibration, Absorption, Distribution, Metabolism and Response
T or F? Excretion/Elimination is a process in which unmetabolized drug is rapidly excretedTrue
T or F? Slow absorption due to slow liberation can still provide normal bioavailabilityTrue, example is Delayed or Extended Release drugs
T or F? The higher the concentration of dissolved drug, the faster the absorptionTrue
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Question Answer
Distribution process is rapid relative/dependent on ---------liberation/dissociation, absorption and metabolism/excretion
T or F? Distribution is adjustable through localization of administered doseTrue, example is topical, Nasal and ophthalmic delivery system
If a constant concentration of drug in the blood stream is to be desired/achieved, what is the equation?THE RATE OF LIBERATION or absorption must be EQUAL TO THE RATE OF METABOLISM + EXCRETION
Response meansBiological effects
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Question Answer
4 things about pharmacokinetics (1)(1) Calculates the rate/amount of drug concentration in the body
4 things about pharmacokinetics (2)(2) Calculates the rate/amount of drug liberation
4 things about pharmacokinetics (3)(3) Calculates the rate/amount of drug metabolized
4 things about pharmacokinetics (4)(4) Calculates the rate/amount of drug excreted
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Question Answer
T or F? Pharmacokinetics only deals with the calculation of drug utilizationTrue
What is the typical value of rate consistence of pharmacodynamicsklib > kdist > kabs > (kmetab + kelim)
What does this equation means klib < kabs < kdist?It means pharmacokinetics of a drug can be altered by making rate of liberation/release slower than those of absorption and distribution (aka Delayed release)
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Question Answer
Pharmacodynamics only deals with ------ of the drug in the body?drug response
T or F? Pharmacodynamics is the rate and extent of desired physiological or biochemical RESPONSE by the bodyTrue
T or F? Pharmacodynamics is in RESPONSE to a specific amount of drug administeredTrue
T or F? Pharmacodynamics is in RESPONSE to a specific amount of drug concentration present in the bloodstream or target tissueTrue
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Question Answer
What are the factors to consider when making a choice of administration route (1)(1) Locale (systemic of topical)
What are the factors to consider when making a choice of administration route (2)(2) Environment (Moisture or pH of the environment)
What are the factors to consider when making a choice of administration route (3)(3) Access (distance from site of application to infected area)
What are the factors to consider when making a choice of administration route (4)(4) Drug absorption (could there be any form of barrier to drug penetration into the blood)
What are the factors to consider when making a choice of administration route (5)(5) Targeting (is the going to target a localized/ topicalized area, if so increase the concentration)
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