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Pharmaceutics III Lecture 10 Modified delivery Part 2

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alchemist04's version from 2016-06-05 22:43

Section

Question Answer
Disadv. of Modified delivery (1)(1) No need for assistance per administration
Disadv. of Modified delivery (2)(2) Hard to discontinue therapy once the drug is ingested (per SR and CR)
Disadv. of Modified delivery (3)(3) Toxicity potential
Disadv. of Modified delivery (4)(4) Cost more to develop, produce and prescribe
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Question Answer
Adv. of Buccal/Sublingual over oral (1)(1) more rapid onset of drug (direct effect like nasal drops, achievable via low MW lipophilic drugs)
Adv. of Buccal/Sublingual over oral (2)(2) reduced drug metabolism (no 1st pass, no liver metabolism, drug doses from mouth to systemic circulation)
Adv. of Buccal/Sublingual over oral (3)(3) potential prolongation of therapeutic effects (Lozenge, slowly dissolve)
Adv. of Buccal/Sublingual over oral (4)(4) Vomiting patient or difficult swallowing
Adv. of Buccal/Sublingual over oral (5)(5) risk of gastric acid (if ingesting drug would cause damages to the drug)
Adv. of Buccal/Sublingual over oral (6)(6) prolonged drug release/duration (better than SR wh/ is limited by GI transits).
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Question Answer
T or F? Small surface area of a buccal patch leads to slow absorption and cause delay release of the drug to the bloodstreamTrue
Requirements for buccal/sublingual deliver are?(1) Hydrophilicity (2) Low M.W. (3) High potency (means fully concentrated with drug substance)
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Question Answer
Problems w/ Buccal/Sublingual delivery (1)(1) less permeable than the intestine (slow permeability due to mouth mucosa)
Problems w/ Buccal/Sublingual delivery (2)(2) Less surface area than intestine for absorption
Problems w/ Buccal/Sublingual delivery (3)(3) Only useful for high potent drug and low M.W. drug
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Question Answer
Adv. of Pulmonary (for lungs) delivery (1)(1) Rapid onset
Adv. of Pulmonary (for lungs) delivery (2)(2) Localized
Adv. of Pulmonary (for lungs) delivery (3)(3) require smaller dose
Adv. of Pulmonary (for lungs) delivery (4)(4) avoid 1st pass/systemic metabolism
Adv. of Pulmonary (for lungs) delivery (5)(5) avoid GI effects
Adv. of Pulmonary (for lungs) delivery (6)(6) Cmax, Tmax and bioavailability is almost equal to that of I.V.
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Question Answer
Only one Limitation/disadvantage of pulmonary delivery, what is itIrritation of critical organ like site of application or absorption
T or F? Bioavailability of drug can be slowed down with food (slowing down the GI motility)True
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Question Answer
Adv. of Parenteral/Nasal delivery (1)(1) Rapid onset (that is close to that of I.V.)
Adv. of Parenteral/Nasal delivery (2)(2) High bioavailability (that is equal to that of i.v. and more than that of IR tablet, DR tablet, SC/IM injections)
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Question Answer
Adv. of Transdermal delivery (1)(1) Avoid GI tract
Adv. of Transdermal delivery (2)(2) Reduce 1 pass
Adv. of Transdermal delivery (3)(3) Long duration via (Sustained release)
Adv. of Transdermal delivery (4)(4) Could deliver drugs more than 24 hrs to days.
Adv. of Transdermal delivery (5)(5) Localized
Adv. of Transdermal delivery (6)(6) require small dose for local effect
Adv. of Transdermal delivery (7)(7) Side effects at the minimum
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Question Answer
Disadv. of Transdermal drug delivery (1)(1) Skin limitation (drug w/ high M.W cannot penetrate skin), limit types of drug that could be applied via Transdermal
Disadv. of Transdermal drug delivery (2)(2) Surface area is small
Disadv. of Transdermal drug delivery (3)(3) High potency
Disadv. of Transdermal drug delivery (4)(4) Lag Time exist btw administration and onset effect. Hence, no fast onset.
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Question Answer
Adv. of Topical drug delivery (1)(1) Localized effect
Adv. of Topical drug delivery (2)(2) Smaller dose is required
Adv. of Topical drug delivery (3)(3) Side effect is minimized
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Question Answer
What are the rational for modified drug delivery? (1)(1) Improved compliance
What are the rational for modified drug delivery? (2)(2) Improve drug therapy
What are the rational for modified drug delivery? (3)(3) Reduced side effects
What are the rational for modified drug delivery? (4)(4) Less frequency (like few times of administration per day e.g transdermal patch)
What are the rational for modified drug delivery? (4)(4) Ease of administration/self dose
What are the rational for modified drug delivery? (5)(5) Lower Cmax = lower side effects
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Question Answer
T or F? Prompt Release is the same as IR and standard tables (Suspension, capsules and uncoated tablets)True
T or F? Prompt Release drug has the same plasma concentration similar to SC and IM injectionsTrue
T or F? Prompt Release is not the same as Coated tablets or modified drugs True
Dissolved drug is typically available for intestinal absorption w/n ----- to ----- mins20 to 30 mins
T or F AUC, Cmax and Tmax depends on the drug rather than the delivery systemTrue
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Question Answer
3 things about Delayed Release tablets (1)(1) released a defined fraction of drug at a time other than first administration
3 things about Delayed Release tablets (2)(2) repetitive or intermittent dosing/drug release w/n one dosage from or administration
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Question Answer
One factor of Delayed Release tablets (1)(1) a fraction is released at a given time
One factor of Delayed Release tablets (2)(2) repetitive supply of dosing/drug release
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Question Answer
T or F? In ER or LA, therapeutic drug concentrations of drug in plasma is maintained for a longer time than prompt release (IR, Solution, Suspension, Emulsion)True
One thing about ER, LA isLonger therapeutic duration greater than that of IR
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Question Answer
6 things about Sustained Release (SR) (1)(1) more than double (like tripling) the duration of drug in the bloodstream
6 things about Sustained Release (SR) (2)(2) Drug stayed (sustained) longer in the blood
6 things about Sustained Release (SR) (3)(3) Reduce drug dosing frequency at least two fold, compared to IR
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Question Answer
6 things about Sustained Release (SR) (4)(4) Cmax may be reduced
6 things about Sustained Release (SR) (5)(5) Tmax may be prolonged
6 things about Sustained Release (SR) (6)(6) AUC per tablet usually increases
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Question Answer
T or F? Tmax is controlled more by the rate constant for drug liberation than the one for drug absorptionTrue
T or F? Constant drug plasma levels would be BEST achieved by a Sustained Release drug delivery systemFalse, Constant drug plasma is BEST achieved by Controlled Release (C for C)
T of F? Prolonged Release is used to achieve constant drug levelsFalse, Prolonged Release extends duration of action of drug when compared to IR but does not achieved constant drug release
T or F? Controlled Release has less side effect than IR because it stays within therapeutic range (MTC and MEC)True
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Question Answer
One thing about Controlled Release (CR) drug (1)(1) provide constant and consistent of drug release into the blood stream and ensure constant and consistent blood concentration levels of drug in the blood
One thing about Controlled Release (CR) drug (2)(2) Cmax is controlled by the rate constant of drug liberation
One thing about Controlled Release (CR) drug (3)(3) Tmax is controlled by rate constant of drug liberation
One thing about Controlled Release (CR) drug (4)(4) AUC could be large bc of constant blood drug level
memorize