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Pharmaceutics III Lect 9 Tablets and Coated Tablets

rename
alchemist04's version from 2016-06-04 01:53

Section

Question Answer
Advantages of Tablets (1)(1) Patient Convenience
Advantages of Tablets (2)(2) Dosing accuracy
Advantages of Tablets (3)(3) High drug stability (relative to capsules)
Advantages of Tablets (4)(4) Low manufacturing cost
Advantages of Tablets (5)(5) Ability to control timing and duration of drug release into the body
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Question Answer
What are the characteristics of tablets (1)(1) Shape and unique design
What are the characteristics of tablets (2)(2) Color, monogram, impression, scored and grooved
What are the characteristics of tablets (3)(3) Thickness
What are the characteristics of tablets (4)(4) Weight
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Question Answer
What are the qualities found in tablets (1)(1) Correct dose.
What are the qualities found in tablets (2)(2) Limited impurities
What are the qualities found in tablets (3)(3) Correct disintegration/drug release and drug release rate
What are the qualities found in tablets (4)(4) Homogeneity
What are the qualities found in tablets (5)(5) Limited friability
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Question Answer
T or F? Shelf life is established during the formulation development of each drugTrue
T or F? The goal of of tablet per shelf life is to develop a formulation that can assure at least a two year shelf lifeTrue
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Question Answer
3 things about fillers (1)(1) Largest component of tablet composition
3 things about fillers (2)(2) Use to dilute POTENT drug to allow convenient tablet weights, to provide mass and size
3 things about fillers (3)(3) Chemically and biologically inert
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Question Answer
Three things about Binder (1)(1) Use to hold drug and FILLERS together
Three things about Binder (2)(2) Typically soluble in water (if tablet contains non ionized drug)
Three things about Binder (3)(3) could be soluble in Alcohol and acetone, if tablet contains the small salt form of a drug.
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Question Answer
One thing about disintegrant (1)(1) Absorbs water and swell to a large volume
One thing about disintegrant (2)(2) Breaks apart compressed tablet matrix allowing more rapid contact between drug and water/stomach
One thing about disintegrant (3)(3) helps with drug dissociation
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Question Answer
One thing about lubricantprevents sticking to dies and molding of drugs
One thing about Glidant(1) Prevent agglomeration (2) keep powders and granules from CLUMPING as mold is filled. (3) prevent tablet from sticking during manufacturing.
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Question Answer
2 things about IR tablets (1)(1) contain high level of disintegrant
2 things about IR tablets (2)(2) results in drug COMPLETELY exposed to gastric fluid w/n a few minutes.
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Question Answer
What makes Chewable tablets different from IR (1)(1) Contains mainly of Mannitol as excipient
What makes Chewable tablets different from IR (2)(2) Contain nonhygroscopic molecules that prevent collection of moisture
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Question Answer
What makes Rapidly Dissolving tablets different from IR (1)(1) Dissolve in mouth w/n 10-15 secs
What makes Rapidly Dissolving tablets different from IR (2)(2) Used for delivery of anti-nausea drugs
What makes Rapidly Dissolving tablets different from IR (3)(3) Manufactured by low force compression of large volume or by lypophilization
What makes Rapidly Dissolving tablets different from IR (4)(4) Are FRIABLE and require individual protective packaging
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Question Answer
T or F? The rationale for "IR" and Rapidly Dissolving tablet is to get drug into the bloodstream as quickly as possibleTrue
What are the advantages of Coated tablets (1)(1) (1) Easier to swallow (2) Taste better (3) Easier to dispense (less friable)
What are the advantages of Coated tablets (2)(2) (1) Prevent tablet from stomach content (2) can modify tablet disintegration or drug dissolution time
What are the advantages of Coated tablets (3)(3) Allow information to printed on each individual dose/drug e.g tablet strength and product ID
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Question Answer
Disadvantages of coated drugs (1)(1) Can affect drug dissolution and disintegration
Disadvantages of coated drugs I2)(2) Can cause modification to tablet disintegration and dissolution
Disadvantages of coated drugs (3)(3) Not for fast onset
Disadvantages of coated drugs (4)(4) can cause a decrease in drug stability by introducing too much moisture into the drug
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Question Answer
Advantages of Film Coated tablets (1)(1) Less fragile/friable (wont break apart)
Advantages of Film Coated tablets (2)(2) easy to swallow (all tablets are easy to swallow)
Advantages of Film Coated tablets (3)(3) Taste better
Advantages of Film Coated tablets (4)(4) Decrease manufacturing time when compared w/ Sugar coated tablet SCT
Advantages of Film Coated tablets (5)(5) Modification of rate at which drug is released (can involve ER or SR or XR)
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Question Answer
T or F? Enteric Film Coated Tablet is the most important Film coated drugsTrue
T or F? Enteric Film Coated Tablet protects drug from stomachTrue
T or F? Enteric Film coated Tablet protect stomach linning from drug irritaionTrue
T or F? Film Coatings can help reduce bitter drug tasteTrue
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Question Answer
Enteric Coated tablet has ------------- coating to resist dissolution in the --------- and then dissolve in an environment that is greater than pH of -------Multiple coating, resist dissolution in the stomach and dissolves in pH > 4.8
Enteric Coating Polymers are (1)(1) Polyvinyl Acetate phthalate
Enteric Coating Polymers are (2)(2) Hydroxypropylmethyl Cellulose phthalate
Enteric Coating Polymers are (3)(3) Cellulose acetate phthalate
Enteric Coating Polymers are (4)(4) Shellac
T or F? Enteric Coatings are basically Phthalates and SHELLacTrue.
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