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Pharmaceutics III Lect 7 Powders and Granules

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alchemist04's version from 2016-06-05 15:25

Section

Question Answer
--------- and ------------- influence the physical and biological properties of powder?Powder shape and size
Particle size can influence (1)(1) Surface area
Particle size can influence (2)(2) Increase in dissolution rate
Particle size can influence (3)(3) Water ADsorption to drug or excipient
Particle size can influence (4)(4) Drug texture or Grittiness.
Particle size can influence (5)(5) Drug powder cohesion
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Question Answer
Particle size can influence (6)(6) Suspendability
Particle size can influence (7)(7) Uniformity of distribution, homogeneity and reproducibility
Particle size can influence (8)(8) Penetrability and reproducibility
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Question Answer
T or F? Particle size does not influence solubility (Quizette)True
T or F? the smaller the powder molecules, the easier it is to homogeniously get into the lungsTrue
T or F? The smaller the fine powder particles, the more difficult it is to suspendTrue
T or F? Small particles are more difficult to redisperseTrue
T or F? The smaller the powder particle, the easier it is to penetrateTrue
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Question Answer
Particle shape can influence (1)(1) Bulk cohesion
Particle shape can influence (2)(2) Agglomeration
T or F? Bulk Cohesion is worst in flat particlesTrue, bulk cohesion is worse in flat particles
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Question Answer
4 things about sieving (1)(1) Provides actual size instead of apparent size of distribution
4 things about sieving (2)(2) Shakes known weight of substance thru stacked of screens
4 things about sieving (3)(3) Sieve openings progressively decrease in size
4 things about sieving (4)(4) weigh amount of powder which collects/cannot pass through the screen
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Question Answer
Four things about microscopic method (1)(1) provides actual size rather than apparent size
Four things about microscopic method (2)(2) it is time intensive
Four things about microscopic method (3)(3) determine both size range and shape
Four things about microscopic method (4)(4) can count number of particles in visual field in each of several dimension ranges
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Attrition is (1)(1) Simultaneously blend and reduce particle size
Attrition is (2)(2) application of shear and pressure
Attrition is (3)(3) Use of Mortal and Pestle
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Levigation is (1)(1) separation of particles from sticking together during grinding
Levigation is (2)(2) using non solvent to decrease agglomeration
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Impaction is (1)(1) milling
Impaction is (2)(2) crushing and shattering of fast moving particles under rapid force/pressure
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Question Answer
Agglomerated fine powders can effect (1)(1) homogeneity of final mixture
Agglomerated fine powders can effect (2)(2) results in variability of administered drug
Agglomerated fine powders can effect (3)(3) variability of drug release rate from sustained release tablets
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Question Answer
Blending powder entails?dilution, mixture of homogeneous and can employ vehicles
Spatulation isspreading into thin layer, mixing by recombining into single bolus mass
Tritulation is (1)(1) Perform using Mortal and Pestile
Tritulation is (2)(2) used for deagglomeration
Trituration is (3)(3) Slow stepwise addition of one powder to another or liquid to a powder
T or F? Triturtaion results in the highest possible homogeneity of drug in solid excipientTrue
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Question Answer
T or F? Granulation is as a result of agglomeration of small particles into larger particles which do not easily break apartTrue
Advantages of granulations (1)(1) simplify dispensing
Advantages of Granulation (2)(2) improve adhension btw powder agglomerates, flow and pour properties of bulk material
Advantages of Granulation (3)(3) Decrease dissolution rate of drug
Advantages of Granulation (4)(4) Less scattering of potent drugs during dosage form manufacture
Advantages of Granulation (5)(5) Better cohesion btw large, deformable homogenous granules
Advantages of Granulation (6)(6) allows preparation of tablets w/desirable properties
Advantages of Granulation (7)(7) difficult to chip and rapidly disintergrate
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Question Answer
Potential problems during processing includes (1)(1) segregation upon mechanical agitation
Potential problems during processing includes (2)(2) adsorption of water to drug
Potential problems during processing includes (3)(3) increased cohesion btw particles
Potential problems during processing includes (4)(4) caking
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Question Answer
Caking can be reduced by (1)(1) maintaining low moisture content
Caking can be reduced by (2)(2) blending in a second powder component which does not cake
What is the best way to dilute solid drug with solid excipient?repetitively add small aliquots of excipient to the total amount of drug, with through mixing between each addition.
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