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Pharmaceutics III Lect. 13 Aerosols, Pulmonary, Nasal Delivery

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alchemist04's version from 2016-06-06 03:23

Section

Question Answer
Adv. of Droplet Spray or Mist Aerosols (1)(1) Can have wide range of dose delivery
Adv. of Droplet Spray or Mist Aerosols (2)(2) Could be used to deliver protein/peptide drug (Systemic delivery)
Adv. of Droplet Spray or Mist Aerosols (3)(3) High permeability.
Adv. of Droplet Spray or Mist Aerosols (4)(4) Provide rapid onset
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Question Answer
Disadv. of Droplet Spray or Mist Aerosols? (1)(1) Inaccuracy of dose delivery
Disadv. of Droplet Spray or Mist Aerosols? (2)(2) can only deliver less than 100 uL per dose
Disadv. of Droplet Spray or Mist Aerosols? (3)(3) Irritation at the site of delivery
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Question Answer
Adv. of Gas Aerosols (1)(1) delivery w/o contamination
Adv. of Gas Aerosols (2)(2) meter value helps with accuracy of drug delivery
Adv. of Gas Aerosols (3)(3) may avoid systemic delivery and may allow systemic delivery.
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Question Answer
Disadv. of Gas Aerosols (1)(1) Can only deliver less than 100 mcg per dose
Disadv. of Gas Aerosols (2)(2) Irritation at the site of delivery
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Question Answer
T or F? Only 5-10% of an inhaled dose may actually reach the appropriate region of the lungsTrue
T of F? Dosing Delivery efficacy, accuracy and reproducibility depend on particle size and patient techniquesTrue
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Question Answer
< 1 isEfficacy range of Inhaled and Exhaled out of lungs (diffusion)
1-5 isEfficacy range of Bronchi and alveoli (Sedimentation)
5-10 isEfficacy range of Upper airways (Impaction)
> 10 isEfficacy range of Oropharynx/swallowed (impaction)
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Question Answer
T or F? Patient activated inhaler is not as accurate as the Meter Dose inhaler (MDI)True
T or F? MDI readily delivers drug particles having desirable size rangeTrue
T or F? the greatest problem of MDIs is the dosing techniqueTrue
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Question Answer
Problems with MDIs (1)(1) Moisture could get inside the canister
Problems with MDIs (2)(2) Agglomeration could occur
Problems with MDIs (3)(3) Dose delivery could be small
Problems with MDIs (4)(4) Accuracy could depend on patients technique
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