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Pharma side effects, immunology,CVS

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summerahmed's version from 2015-07-20 10:09

immunology:

 

Question Answer
cyclosporinenephrotoxicity, htn, hyperlipideamia, neurotoxicity, gingival hyperplasia, hirsutism
tacrolimus FK506increse risk of DM, neurotoxic, nephrotoxic, hyperlipidemia and htn
sirolimus ( rapamycin)anemia, thrombocytopenia, leukopenia, insulin resistance, hyperlipidemia and not nephrotoxic
daclizumanedema, htn, tremor
basiliximabdema , htn , tremor
azathioprineleucopenia, anemia, thrombocytopenia
glucocorticoidshyperglycemia, osteoprosis, central obesity, ms. breakdown, psychosis, acne, hypertension, cataract, avascular necrosis
adalimumabTB reinfection by inhibiting the TNFalpha
infliximabTB reinfection by inhibiting the TNFalpha
natalizumabalpha-1-integrin WBC adhesion risk of PML in patients with JC virus
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CVS:

Question Answer
CCB- dihydropyridine ( amlodipine, clevidipine, nicardipine, nefidepine, nimodipine)peripheral edema, flushing, dizziness, constipation, gingival hyperplasia
CCB-non fihydropyridine ( diltiazim, verapamil )cardiac depression, AV block, verapamil causes hyperprolactinemia, flushing, dizziness, gingival hyperplasia
hydralazinecompensatory tachycardia ( contraindicated in angina/CAD), fluid retention, headache, angina, lopus-like syndrome
nitroprussidecyanide toxicity
fenoldopamD1 agonist, htn emergency VD, decreases the blood pressure and increases the natriuresis
nitrates (nitroglycriene, isosorbide dinitrite/ mononitrite)reflex tachycardia - ttt by beta blocker-, hypotension, flushing, headache, monday dse: in industruial exposure development of tolerance to VD acting during the weekdays and the loss of tolerance during the weekend results in the symptoms of tachycardia, dizziness, headache upon reexposure
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Endocrine :