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Pharma Credit 1- beta Lactams

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miko1587's version from 2017-11-21 16:30

Section 1

Question Answer
Narrow Spectrum Penicillins ( Penase- susceptible) Penicillin G/V
Penicillin G/V Clinical Use Streptococcal/ Meningococcal Infections/ Syphillis
Narrow Spectrum Penicillins ( Penase- susceptible) Kineticsrapid elimination/ short half life
Narrow Spectrum Penicillins ( Penase- resistant) Nafcillin/ Oxacillin
Narrow Spectrum Penicillins ( Penase- resistant) Clinical UseStaphylococcal Infections
Narrow Spectrum Penicillins ( Penase- resistant) Kineticsbiliary clearance
Penicillins Toxicities 1Hypersensitivity
Penicillins Toxicities 2GI Distress
Ampicillin ToxicitiesMaculopapular rash
Wider Spectrum Penicillinase Ampicillin Amoxicillin Piperacillin Ticarcillin
Clavulonic acid is Amoxicillin/ Augmentin
Clavulonic acid is used to treat Community aquired pneumonia
Carboxypenicillins are Ticarcillin Carbenicillin
Carboxypenicillins toxicities are Hyperensativity/ Nicolas Hoigenes syndrome/ Steven Johnson syndrome
Anti-pseudomedmonas drugs Carboxypenicillins/ Ureidopencillins
Mild allergy to penacillin alternative Cephalosporine
Severe allergy to penacillin alternative Macrolide: Erythromycin
Ureidopenicillin Piperacillin/ Mezlocillin/ Azlocillin
Penicillin G is 1st line treatment for Syphilis
Penicillins are bacteriocidal or bacteriostatic?Bactercidal
memorize

Section 2

 

Question Answer
Cephalosporins are bacteriostatic or bacteriocidal?bactericidal
Mechanism of Action of Cephalosporins?Inhibit cell wall then bind to PBP
Cephalosporin is which type of antibiotic?B-lactam
Which generation of cephalosporins do not cross BBB?1 + 2
Which generation of cephalosporins cross BBB? 3 + 4
Toxicities of Cephalosporins?hypersensativity/ cross reaction with penacillin/ GI Distress
Cephalosporin used for surgical prophylaxis?Cefazolin
Cephalosporin used to cure B. fragilis?Cefotaxime
Cephalosporin used to cure E. coli?Cefuroxime
1st line treatment for Gononnorhea?Ceftriaxone
Treatment for Pseudomonas?Ceftazedime
Cephalosporin used to treat MRSA?Ceftobiprole
1st gen cephalosporins?Cefazolin Cephalexin Cefadroxil
2nd gen cephalosporins?Cefaclor Cefotaxime Cefoxitin Cefuroxime
3rd gen cephalosporins?Ceftriaxone Cefotaxime Ceftazedime
4th gen cephalosporins?Cefepime
5th gen cephalosporins?Ceftanline Ceftobiprole
Which cephalosporin is b-lactam stable and its generation?Cefepime 4th
memorize

Section 3

Question Answer
Monobactam is what kind of antibiotic?B-lactam
Name a type of monobactam antibiotic?Aztreonam
Aztreonam can be used to treat?Pseudomonas
Kinetics of Aztreonam?Parenteral/ renal elimination
Mechanism of Monobactams?cell wall inhibitors/ bind to PBP3
Toxicities of Aztreonam?GI/ Headache/ vertigo/ no cross reaction
Carbapenems antibiotics?Imipenem/ Doripenem/ Meropenem/ Ertapenem
Impipenem + Aminoglycosides is used to treat? Pseudomonas
Glycopeptides are which spectrum?Narrow
Types of Glycopedtide antibiotics?Vanco Teicoplanin Televancin Dalbavancin
Vancomyacin is 2nd line to treat?C-diff
Glycopeptide is bacteriostatic or bacteriocidal?bacteriocidal
Toxicity of Glycopeptide?Ototoxicity/ Nephrotoxicity
Vancomyacin Toxicity?Red Man Syndrome
memorize

Section 4

Section 5

Section 6