Create
Learn
Share

Pharm39

rename
robbypowell's version from 2016-12-13 00:46

Drug Interactions

Question Answer
______ ______ are measurable modification (in magnification or duration) of action of 1 drug by prior or concomitant admin of another substance (Rx or OTC, food or alcohol)Drug Interactions
T/F: Drug interactions can be desirableTrue (where interactions allow lower dosage of one drug to be administered to achieve therapeutic effects)
T/F: Drug Interaction are always undesirable, as they alter drugs designed effectFalse (can be beneficial where interactions allow lower dosage of one drug to be administered to achieve therapeutic effects; or inconsequential)
There are over ______ serious adverse drug reactions every year, leading to ______ deaths per year2 million; 100k
T/F: Adverse drug reactions are the 4th leading cause of deathTrue
Adverse drug rxn's are the cause of ______ deaths per year in nursing homes350k (yeah, i know.. it said only 100k ppl die every year from drug reactions.. so Moz is saying nursing home residents aren't people... that or its also counting mice popping multiple of the residents pills)
Averse reactions increase exponentially with _________ or more meds4+
T/F: the relationship between number of meds prescribed to patient and adverse drug interactions is linearFalse (exponential)
______ interaction is due to improper mixing/manufacturing of drugPharmaceutical
______ interaction is due to metabolism, excretion, etcPharmacokinetic
______ interaction is due to alteration of either transmitter, receptor and/or second messenger systemsPharmacodynamic
Tetracycline and Ca (in milk or antacids) form an insoluble salt and so drug cannot be absorbed well. this is an example _____ formation and is a type of Absorption interferenceComplex formation (Cholestyramine & Cardiac Glycosides or thyroxin is another example)
Atropine and opiate-like drugs slow the rate of absorption of acetaminophen by altering ______ _____Intestinal Motility
an example of "attenuated absorption", phenytoin/Dilantin and oral contraceptives inhib hydrolysis of ____ ___ in gut and dec absorptionFolic Acid
pH in stomach can affect absorption of some drugs ... what is an example of a drug that has lower absorption at more acidic pH? more alkaline pH?Penicillin (don't take w fruit juice); Ketoconazole (do take w fruit juice)
______ (chemical) increases release of adrenergic NT's when taken with MAO-inhibitors and can cause headaches and hypertensive crisisTyramine (in meats, cheeses, dairy products)
NSAID's and BZD's have very high plasma protein binding... so any decrease in plasma binding would cause a _______ (greater/lesser) effectgreater effect (only free drug acts)
Coumarin anticoagulants, Salicylates and NSAID's have _____ (high/low) protein binding, making them susceptible to Distribution effectsHigh
Phase ____ (1 or 2) Hepatic drug metabolism: oxidation, reduction, hydrolysis, hetpatic mixed-function oxidase sys1
Phase ____ (1 or 2) Hepatic drug metabolism: conjugation with glucuronide, sulfate, glycine2 (more soluble form of drug is excreted via urine/bile)
5 drug (classes) that act as Inducers of hepatic metabolismBarbiturates, Carbamazepine, phenytoin, primodine, rifampin
Barbiturates, Carbamazepine, phenytoin, primodine, rifampin are all ______ of Hepatic metabolism and ______ (increase/decrease) duration of co-administered drugs that are metabolized by liverInducers; Decrease
Cimetidine, ethanol (acute admin), metronidazole, verapamil, diltiazem, ciprofloxacin are all ______ of Hepatic metabolism and ______ (increase/decrease) duration of co-administered drugs that are metabolized by liverInhibitors; Increase
Which of these drugs is NOT A Hepatic Metabolism INDUCER: Barbiturates, Carbamazepine, phenytoin, cimetidine, rifampinCimetidine (inhibitor)
Which of these drugs is NOT A Hepatic Metabolism INDUCER: Barbiturates, Carbamazepine, phenytoin, primodine, ethanol ethanol (inhibitor)
Which of these drugs is NOT A Hepatic Metabolism INDUCER: Barbiturates, Carbamazepine, metronidazole, primodine, rifampinmetronidazole (inhibitor)
Which of these drugs is NOT A Hepatic Metabolism INDUCER: Barbiturates, verapamil, phenytoin, primodine, rifampinverapamil (inhibitor)
Which of these drugs is NOT A Hepatic Metabolism INDUCER: ciprofloxacin, Carbamazepine, phenytoin, primodine, rifampinciprofloxacin (inhibitor)
changes in renal excretion can cause changes in excretion of drugs... more acidic urine (caused by ammonium chloride e.g.) will increase the excretion of weak _______ (acids/bases)weak BASES (more acidic urine increases excretion of basic drugs; Local Anesthesia e.g.)
changes in renal excretion can cause changes in excretion of drugs... more basic urine (caused by NaHCO3 e.g.) will increase the excretion of weak _______ (acids/bases)weak ACIDS (more basic urine increases excretion of acidic drugs; such as Aspirin and Penicillin)
Because of competition at the level of proximal tubular transport system, _______ decreases the excretion rate of PenicillinProbenecid***
Probenecid decrease excretion of what.... due to competition at the level of proximal tubular transport systemPenicillin***
Some diuretics can cause Hypo-______ which potentiates Digitalis toxicityHypokalemia
Some diuretics can cause Hypokalemia which potentiates _______ toxicityDigitalis
T/F: Patients with impaired kidney function may need lower doses of drugs that are excreted renallyTrue (e.g. Penicillin)
Which of the following is an example of Pharmacologic Antagonism: 1) Adrenergic & Cholinergic blockers, 2) Bactericidal & Bacteriostatic antibiotics, 3) CNS stimulants and depressantsAll of the above
Which of the following is an example of Pharmacokinetic Antagonism: 1) Adrenergic & Cholinergic blockers, 2) Bactericidal & Bacteriostatic antibiotics, 3) CNS stimulants and depressantsNone of the above (these are all Pharmacologic Antagonism)
Epinephrine is a __________ antagonist of HistaminePhysiologic Antagonist
memorize

Recent badges