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robbypowell's version from 2016-10-25 00:29

Dyslipidemia

Question Answer
Drug class that is the First line drugs for treatment of hyperlipidemia bc they block the rate limiting enzyme in biosynthesis of cholesterolHMG-CoA Reductase Inhibitors (**TEST**)
drugs that end in -statin are of what drug class?HMG-CoA Reductase Inhibitors (lipid lowering drugs)
Drug that affects cholesterol levels by acting directly on cholesterol in the blood, not by affecting its synthesisCholestyramine
This drug is a Tri-glyceride synthesis decreaserNiacin
This drug increases lipoprotein lipase activityClofribate
This drug acts by inhibiting cholesterol absorptionEzetimibe (Zetia)
This drug lowers tri-glyceride synthesis by affecting gene transcription factor (Peroxisome proliferator activated receptor alpha) (PPAR-alpha agonist)Gemfibrozil (only one we know that affect genetic info)
T/F: usually side-effects from statins are rare... and the drugs are well toleratedTrue
T/F: there is a small risk of diabetes in patients on lipid lowering drugs and so their HbA1c levels should be monitoredTrue
how does Cholestyramine act?binds to cholesterol and decreases levels in blood
how does Niacin affect lipid levels?Decreases Tri-glyceride synthesis
how does Clofribate affect lipid levels?Increases Lipoprotein Lipase activity
HMG-CoA Reductase Inhibitors decrease _____ by _____%LDL; 60%
This drug class causes depletion of intracellular cholesterol and increases uptake of extracellular cholesterolHMG-CoA Reductase Inhibitors
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