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Pharm19

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robbypowell's version from 2016-12-12 20:53

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Question Answer
Postsynaptic nerve terminal is often called ______ cellEffector
Source of Epi & Norepi is _____ → converted to dopa → dopamine → NE → epiTyrosine (or phenylalanine when no Tyrosine)
_____ cells in _____ _______ convert tyr to epi completelychromaffin cells; Adrenal Medulla
T/F: NT's get released in synaptic cleft and binds to receptors to exert their effecttrue
T/F: Primary way of removing NT in biogenic amines (NE, epi, 5HT, etc) is reuptaketrue
T/F: Primary way of removing NT in biogenic amines (NE, epi, 5HT, etc) is degradationFalse
T/F: Cocaine is powerful vasoconstrictor because it inhibits reuptakeTrue
T/F: Cocaine is a powerful vasoconstrictor because it acts as an sympathomimeticFalse (i think... at least not statement he gave us)
TRitillium inhibits release of ___ → different mechanismNorepinephrine
T/F: MAO (pre-synaptic) and COMT (post-synaptic)True
T/F: MAO (post-synaptic) and COMT (pre-synaptic)False ((other way around
________ (drug class) have lots of side effects and CNS effects → reserved mainly for atypical depressionMAO Inhibitors
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adrenergic receptor table

Question Answer
What type adrenergic receptor associated with most blood vesselsA1
What type adrenergic receptor associated with CNS and Presynaptic actionA2
What type adrenergic receptor associated with HeartB1
What type adrenergic receptor associated with Lung/airway SM, some blood vesselsB2
What are 2 other stimulants (natural) for A1 receptors (in addition to Norepi)Epinephrine & Phenylepinephrine
What is another stimulant for A2 receptors (in addition to Norepi)Clonidine
What are 2 other stimulants for B1 receptors (in addition to Norepi)Isoproterenol & Dobutamine
What are 4 other stimulants for B2 receptors (in addition to Norepi)Albuterol, Terbutaline, Metaproterenol, & Bitolterol
T/F: Amphetamines are Indirect-acting SympathomimeticsTrue
T/F: Amphetamines are NE reuptake blockersFalse (indirect Sympathomimetic)
T/F: A2 receptors are PREsynaptic, but rest of alpha receptors are POSTsynapticTrue
T/F: A1 receptors are PREsynaptic, but rest of alpha receptors are POSTsynapticFalse (A2)
_____ (alpha/beta) receptors respond better to NE, then epi, and last isoproterenol; opposite effect in _____ receptors (iso > epi > NE)Alpha; Beta
you Can use ________ for asthma because it more selectively binds to B2 receptors = bronchodilation (more potent effect than epi bc of higher binding affinity)Isopr
______ blocks a1 receptors (anti-HTN)Prazosin
_______ is effective a2 agonist = used for Anti-HTNClonidin
Terbutaline, Albuterol, metaproterenol, and bitolterol are effective selective ___ agonist = asthma medB2
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