olola's version from 2016-10-04 10:34


Question Answer
What is the current drug of choice for status epilepticus?Diazepam (valium)
what opioid can be given as an anti-diarrheal and anti-tussive?Codeine
What non-opioid analgesic does not have anti-inflammatory properties?Acetaminophen (APAP)
T/F: Withdraw a person wI chronic ethanol dependence wI decreasing doses of morphineFALSE
T/F: Oxazepam is given for anxiety controlTRUE
T/F: Interaction between meriperideine and MAOI include excitation, seizures, coma, apneaTRUE
T/F: Barbitruates and Phenytonin induce microsomal enzyme activitytrue(?)
T/F: Xerostomia is greater wI SSRIs than TCAFalse
T/F: Tramadol is a novel NSAIDFALSE
T/F: Hypotension secondary to acute opioid intoxication is due to activation of vasomotor centerFALSE
T/F: Midazolam (versed)-duration of action is shorter than diazepamTRUE (more potent, less duration than diazepam)
T/F: Acetaminophen causes hepatotoxicityTrue (MC question reads "which drug causes hepatotoxicity" and Acetaminophen is the answer)
T/F: Narcotic analgesics affect the CNS by inducing resp depression, nauseas, hypotensionTRUE
T/F: Barbiturates cause increase in GABA binding and decrease duration of CI channel openingFalse (question is "all is true of barbiturates except" and this is the false answer)
Clonidine suppress the _______ nervous system (bind to alpha 2 receptor)Sympathetic
Lidocaine is a _______ channel blockerSodium (Na)
T/F: Merperidine will have less addiction potential than morphineFALSE (apparently)
T/F: NSAIDS cause drowsiness and urinary retentionFALSE (opioids)
T/F: Morphine, through direct stimulation of chemoreceptor trigger zone in medulla oblongata, produces vomitTRUE
Put in order of onset from fastest to slowest: Pentobarbital, Phenobarbital, ThiopentalThiopental (fast acting, short duration) >> Pentobarb (moderate onset and duration) > Phenobarb (long acting, slower onset)
Morphine binds to _________ receptor and causes supraspinal analgesiaMu (Mu1 specifically for supra spinal)
T/F: Ketorolac can cause nephrotixicityTrue (its use should be limited to 4 days)
T/F: BBB is highly permeable to hydrophilic drugFALSE
T/F: both midazolam and diazepam causes anterograde amnesiaTRUE
T/F: an opium derivative can be used to treat diarrheaTrue
Know the 2 narcotic antagonistsNaloxone (IV) and Naltrexone (oral)
T/F: Meperidine had Atropine like acitivity thereby causes less papillary constrictionTRUE
T/F: NSAIDs have a plateau effect for analgesiaTrue
T/F: Morphine is thought to produce orthostatic hypotension by activation of vasomotor centerFALSE (by decreasing peripheral vascular response)
T/F: Oxazepam interacts with primarily with central glutamate receptorsFALSE
T/F: Diazepam is capable of producing hostility + Of - anxietyTRUE
Thrombophelibitis which occurs after IV admin of diazepam soln is usually attributed to ____ ____ in the mixture?Propylene glycol
T/F: Acetaminophen is preferred over aspirin in pt. on coumadinTrue
_____ is a narcotic antagonist/agonistPentazocine
T/F: NT release involves Mem dep. And activation of voltage-gates K+ channelsFALSE
T/F: NT release involves Activation of voltage-gated CA2+ channelsTRUE
T/F: NT release involves Fusion of synaptic vesicles with presynaptic membraneTRUE
T/F: Fentanyl can induce general anesthesiaTrue
T/F: Subcortical site is the most imp!. Area for the central skeletal ms. Relaxant effect of valiumTRUE
T/F: Methodone potentiates the euphoria of heroineFalse
T/F: analog encoding consist of the frequency of action potentials and can be inhibited by ion channel blockersFalse (digital)
T/F: Propoxyphen has the same action as oxycodoneFalse
T/F: Kidney damage from long term use is a side effect go AcetaminophenTrue
As its mechanism of action, aspirin has been shown to inhibit what enzyme?COX (which was not an answer on MC, so none of the above)
T/F: Acetylcholine is an excitatory neurotransmitterTrue
T/F: Prednisone does not act by inhibiting COXTrue (question was which of the following does not inhibit COX)
Parkinson's disease is associated with which NT?Dopamine
T/F: Side effects of acetaminophen are hepatotoxicityTrue
T/F: Contraindications for the use of barbiturates include pregnancy and porphyriaTRUE
T/F: Adverse effects ofNSAIDS include gastric irritation, GI bleeding, nephrotoxicityTRUE
T/F: Methemoglobinemia is associated with Acetylsalicylic acidFalse
T/F: Narcotic analgesic affect motivational/affective component of painTRUE
T/F: Barbiturates can cause general anesthesiaTRUE
T/F: Occult bleeding is associated with AcetaminophenFalse (assoc w/ Nsaids and Aspirin)
T/F: So called opioid mu (morphine) receptor in the CNS is the same receptor for enkephalins and endorphinsTRUE
T/F: Management of alveolar ostitis include administration of a combined narcotic and non-narcotic analgesicFalse
T/F: Potent drug stimulation at the CNS is usually followed by depression and the depression is additive with the effects of CNS depressant drugsTRUE
T/F: Kappa receptor mediate miosis, sedation and spinal analgesiaTRUE
T/F: Routine use ofketorlac as a post-op analgesic is recommendedFalse (nephrotoxicity)
T/F: Diphenoxylate (paragonic - used to tx diarrhea) is effective drug to Ix of constipationFalse
T/F: Acetomenophen interferes w platelet aggregationFalse
T/F: Meperidine is longer acting than morphine therefore requiring less freq. administrationFalse (bc it is actually shorter)
T/F: Ibuprofen binds avidly to albumin and undergoes extensive metabolism, glucuronide conjugates are excreted in urineTRUE
T/F: drug-induced central skeletal muscle relaxation is a result of a drug's sedative effect rather than a specific action on CNSFalse
T/F: wider margin of safety, easier sep of anxiolytic effect from sedative effect, lower dependence liability are all advantages of BZD's over BarbituratesTrue
T/F: Either alcohol or corticosteroid can cause increase ulcerogenic effect when used wI aspirinTrue (?)
T/F: Sedative effect is easily separated from relief of anxiety when administering pentobarbital to dental pt.false
T/F: aspirin causes irreversible inhibition of COXTrue
T/F: adverse Gr effects of aspirin include gastric distress, occult bleeding, acute hemorrhageTrue
What is the short to intermediate acting barbiturate?Pentobarbital
Midazolam can be antagonized by ______Flumazenil
T/F: Diarrhea is not a common side-effect of opioidsTrue
T/F: Morphine acts via Presynaptic inhibitionTrue
T/F: Morphine acts via Postsynaptic inhibitionFalse
T/F: GI ulcer aggravation is a side effect of AcetaminophenFalse
T/F: Codeine causes respiratory depression at normal therapeutic dosesTrue
T/F: salicylism is the term applied to syndrome caused by chronic use of aspirinTRUE
T/F: Pentazocine is capable of producing abstinence syndrome in opioid-dependent personTrue
T/F: Acetaminophen may be safely used in pt. w/ history of allergy to phenocetin and acetanildFalse
T/F: Clinical trials have demonstrated that 60 mg of codeine results in greater pain relief following dental procedure than 400 mg of ibuprofenfalse
T/F: mediators of pain and iriflammation include serotonin, histamine, bradykininTrue
T/F: function attributed to dopamine include motor control, behavior and perceptionTRUE
T/F: Acetylcholine is excitatory in natureTrue
T/F: both metabolites of diazepam (oxazepam and desmethyldiazepam) are activeTrue
T/F: opioids have been shown to bind specifically w/ receptor for EnkephalinsTrue (MC w/ Enkephalins as correct answer)
T/F: Hydroxyzine is an antihistamineTrue
What is the NT of nicotinic receptor/muscarineACH
T/F: side effect of acetaminophen - kidney damage on long term use and liver damagetrue
T/F: antipyretic analgeics are ideally suited to tx visceral pain (pain of angina)false
T/F: sedation is drug induced sleep while hypnosis is a state of calmness that often induces drowsinessfalse
T/F: PGE2 desensitizes free nerve endings to algesic mediatorsfalse
T/F: Salicyclism should be treated with N-acteylcysteineFalse (treat w/ Bicarb)
T/F: merperidine is more constipating than morphineFalse
T/F: NSAIDs can exacerbate GI ulcerstrue
T/F: diazepam is contraindic in pt. w/ acute narrow angle glaucomaTrue
T/F: physical dependence and habituation are synonymousfalse
T/F: acetaminophen inhibits platelet aggregation and uric acid secretion but does not cause bleeding or gastric irritationfalse
T/F: aspirin overdose can be effectively tx by decreasing urine pHfalse
T/F: acute toxication w/ meperidine causes CNS excitationtrue
T/F: morphine can aggravate symptoms of prostatic hyperplasiatrue
T/F: smoking may increase effectiveness of diazepamfalse
T/F: diazepam is drug of first choice to tx both status epilepticus and ms contractions of tetanustrue
T/F: oxybarbiturates are a series of agents that contain an oxygen at C2 of barbituric acid ring, while thiobaributrate contain sulfur atom attached to the same carbontrue
Acetylcholine esterase breaks down Acetylcholine into ____ and ____Choline & Acetate
Chloral Hydrate- all of the abovemetabolized to trichloroethanol which accounts for its CNS depressant properties, overdose may lead to cardiotoxicity (arrhythmias), usually combined with hydrazine and promethazine, has minimal effect on REM sleep
Flumazenil - NONE of the aboveNO to GABA potentiation, sodium channel blocker, GABA antagonist, presynaptic inhibitor. It is an antagonist for BZD receptors
Phenobarbital can influence the pharmacokinetics of other drugs bycompeting for plasma binding proteins and stimulating microsomal enzymes
adverse effects of barbituratestolerance and hyperalgesia
T/F: Subcortical site is the most important area for the central skeletal muscles relaxant effect of ValiumTRUE