Pharm - Vaccines

morauch630's version from 2017-11-15 07:28

Defining Immunobiologics

Question Answer
Define immunization:Immunizing is the process of INDUCING or PROVIDING immunity artificially by administering an immunobiologic.
Define active immunity:Immunity generated by a natural immunologic response to an antigen. (YOU MAKE YOUR OWN ANTIBODIES)
Define passive immunity:TEMPORARY immunity to infection as a result of administration of ANTIBODIES NOT produced by the host
What are vaccines made from?from the infecting organism itself
Define Immunoglobin:Antibodies derived from human serum or horse serum Extracted from donor pools of blood plasma and treated to prevent transmission of infectious agents
Define antitoxinsAnimals immunized with antigen and antibodies produced are harvested
Define toxoids:Inactivated bacterial toxins that are combined with aluminum salts to prolong antigen absorption and exposure which leads to an immune response
Side effect of aluminum saltsCan cause local irritation
List four immunobiologicsvaccine, toxoid, immunoglobulins, & antitoxin


Question Answer
What are viral vaccines made from?Live attenuated or killed viral particles or whole virus
Define live attenuated virusVirus is still able to replicate but not at the rate they would normally replicate in the body
What are bacterial vaccines made fromKilled whole bacteria or cell wall fragments

Factors affecting response

Question Answer
What site of administration is best for Hep B vaccineDeltoid

Section 2

Question Answer
Bacille Calmette-Guerin (BCG)‏Live Vaccine
Mycobacterium bovisLive Vaccine
Measles Live Vaccine
MumpsLive Vaccine
RubellaLive Vaccine
Oral typhoid Live Vaccine
Yellow feverLive Vaccine
VaricellaLive Vaccine
Oral polioLive Vaccine
Nasal influenzaLive Vaccine
Cholera Inactivated Vaccine
Haemophilus influenza type BInactivated Vaccine
Injectable InfluenzaInactivated Vaccine
Japenese encephalitisInactivated Vaccine
Lyme diseaseInactivated Vaccine
Meningococcal diseaseInactivated Vaccine
PertussisInactivated Vaccine
Injectable polio Inactivated Vaccine
PneumococcusInactivated Vaccine
RabiesInactivated Vaccine OR immunoglobulin
Injectable typhoid Inactivated Vaccine
TetanusToxoid OR Immunoglobulin
Hepatitis BImmunoglobulin
Varicella – Zoster Immunoglobulin
Rho (D)‏Immunoglobulin
TetanusToxoid OR immunoglobulin

Section 4

Question Answer
Considerations for pregnant women:Pregnancy Live attenuated vaccines should not be given Inactivated vaccines should wait until the second trimester
Considerations for neonates and infants:First few months the immune response is low. Passive immunity
Pts considered to have limited immune deficiency:Renal or liver disease, diabetes, asplenia
Considerations for patients with limited immune deficiency:May need higher doses but they can receive all types of vaccines
Pts considered to have severe immune deficiency (but not HIV):Malignancy, congenital immunodeficiency
Considerations for patients with severe immune deficiency (but not HIV):No live vaccines. Avoid giving vaccines near the start of chemotherapy or radiation therapy Close contacts can receive MMR
Considerations for patients with HIV:Immune response generally low, usual vaccine schedules should be followed. Live vaccines discouraged. Close contacts may be discouraged from live vaccines