Pharm- Pharmacokinetics

ajkim1's version from 2015-06-16 03:10


Question Answer
Constant fraction of drug is eliminated per unit timeFirst order
Between zero order and first order, which is more common amongst medications?First order
Constant amount of drug is metabolized per unit timeZero order
Alters KmCompetitive inhibition
Inhibitor is similar to the substrateCompetitive inhibition
Competes for the active siteCompetitive inhibition
Affinity/potency is decreasedCompetitive inhibition
Km increasesCompetitive inhibition
Vmax does not change if more substrate is addedCompetitive inhibition
ReversibleCompetitive inhibition
Not similar to substrate and does not bind active siteNoncompetitive inhibition
Binds to regulatory siteNoncompetitive inhibition
Turns the enzyme offNoncompetitive inhibition
Km remains the sameNoncompetitive inhibition
Vmax/efficacy decreasesNoncompetitive inhibition
IrreversibleNoncompetitive inhibition
Shifts curve to the rightCompetitive antagonist
Decreases potency/affinityCompetitive antagonist
No change in efficacy/VmaxCompetitive antagonist
Can overcome by increasing agonist substrateCompetitive antagonist
Shifts curve downwardNoncompetitive antagonist
Decreases efficacy/VmaxNoncompetitive antagonist
Cannot be onvercome by increasing agonist substrateNoncompetitive antagonist
Acts at same site as full agonistPartial agonist
Reduced maximal effect, decreases efficacy, but increases/decreases potencyPartial agonist
LD50/ED50Therapeutic index
The higher the TI value, the (safer/unsafer) the drugSafer
Measure of the doses at which a drug can be both safe and effectiveTherapeutic window