Pharm Midterm 1

annire's version from 2016-02-17 07:22

Section 1

Question Answer
astrocytestructural support, environment, nutrient, phagocytosis
oligodendrocyteCNS, multiple, inhibits regrowth
microglialphagocytosis, immune
schwannPS, growth factors, guide axons to targets
Breakdown of PNSautonomic (sympathetic and parasympathetic - internal environment) somatic (motor - skeletal and sensory - external environment and body senses)

Section 2

Question Answer
pharmacokineticswhat the body does to the drug
pharmacodynamicswhat the drug does to the body
bioavailability depends onroutes of administration, absorption and distribution, binding, inactivation, and excretion
types of administrationoral, rectal, inhalation, topical, intranasal, subcutaneous...
fastest adminIV
topicaldirectly to body part
intranasalbypasses bbb
plasma protein bindingabsorbed in bloodstream and binds to proteins

Section 3

Question Answer
what affects absorptionconcentration, metabolism speed, fluid volume, blood flow, ionization
ionization ex:nonionized in stomach can cross into the blood, becomes ionized, cannot cross back
ionization depends on ph of solution and pka of compound
what does a typical capillary have that a brain capillary doesn'tpinocytotic vesicles, intracellular cleft, fenestrations
partial agonistsimilar potency, lower efficacy
inverse agonistopposite effect
antagonistblocks any effects
competitive antagonistneed higher concentration to get the same effects. (lower potency)
noncompetitive shape changes

Section 4

Question Answer
radioligand binding assayradiolabel a ligand
nonspecific bindingmake something compete, something with high affinity for the target. everything left is nonspecifically bound
specific binding = total - nonspecific
scatchard plotslope = 1/Kd. intercept = Bmax. //bound/free vs bound
free = total added - bound
competition curvesdecreases as [inhibitor] increases

Section 5

Question Answer
acetylcholinenicotinic and muscarinic
nicotinic5 subunits, found in presynaptic ganglia of sympathetic and parasympathetic nerves.ionotropic. skeletal muscle of NMJ.
muscarinic7 transmembrane parts. metabotropic. end organs ofparasympatheticnerves
serotoninall metabotropic except for 1. 5HT2A - LSD. 5HT1A - autoreceptor
dopamine D2 D3 autoreceptors all metabotropic
norepinephrineall metabotropic. alpha 2 is autoreceptor. postsynaptic ganglia of sympathetic --> increase blood pressure. bronchal dilation.

Section 6

Question Answer
amphetaminesreverse NE and DA transporters (and block VMAT)
PCP, ketamineNMDA-R agonist
MDMAblocks VMAT, 5HT transporter reverse
LSDstimulate 5HT2A receptors
cocaineinhibits DAT and NET