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Pharm genomics

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mujafayi's version from 2015-05-03 20:39

Section

Question Answer
hlab*5701hypersensitivity
hlab*5801serious derm reactions
hlab*1502serious derm reactions
2c9*1extensive
2c9*2poor
2c9*3poor
2c9*6poor (null)
2c19*1extensive
2c19*2poor
2c19*3poor
2c19*17ultra rapid
2d6*1/*2extensive
2d6*2xNultra rapid
2d6*10poor
2d6*17poor
2d6*3poor (null)
2d6*4poor (null)
2d6*5poor (null)
ugt1a1*1normal
ugt1a1*28poor
nat2*4extensive
nat2*5poor
nat2*6poor
nat2*7poor
slco1b1*1aincreased hepatic uptake
slco1b1*1bincreased hepatic uptake
slco1b1*5decreased hepatic uptake
slco1b1*15decreased hepatic uptake
slco1b1*17decreased hepatic uptake
vkorc1*1normal
vkorc1*2reduced
vkorc1*3increased
adrb1*1normal
adrb1 389decreased receptor sensitivity
adrb1 49increased receptor sensitivity
adrb2*1normal
adrb2 16decreased receptor sensitivity
adrb2 27increased receptor sensitivity
hmgcr snp 12decreased effectiveness
hmgcr snp29decreased effectiveness
g6pd class 4normal
g6pd class 2deficient/decreased enzyme function
g6pd class 3deficient/decreased enzyme function
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drugs

Question Answer
g6pd drugsrasbiuricase, primaquine, sulfonylureas, dapsone
hmgcr drugsstatins
adrb2 drugsbeta2 targeted drugs
adrb1 drugsbeta1 targeted drugs
vkorc drugwarfarin
slco1b1 drugsstatins
nat2 drugsisoniazid, hydralazine, sulfasalazine
ugt1a1 drugirinotecan
2d6 drugsTCA, SSRIs, AP, Codeine, Hydrocodone, Oxycodone, Dextromethophan, Tramadol, Beta Blockers, Antiarrhythmics, Tamoxifen
2c19 drugs clopidogrel, diazepam, TCA, PPI
2c9 drugswarfarin, phenytoin, nsaid, sulfonylureas
hlab* 1502 drugscarbamazepine phenytoin
hlab*5801 drugallopurinol
hlab*5701 drugabacavir
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