Pharm final 2

kelseyfmeyer's version from 2015-05-08 19:22

abx ctd

Question Answer
which abx inhibits Topoisomerase II gyrase enzyme?flouroquinolones (flo gyrates her hips like a top)
metronidazole is good for tx of?protozoans and anaerobes
what is the distribution/absorption/kinetics of flouroquinolones?widely distributed, well absorbed, accumulate in phagocytic cells so affects intracellular pathogens. also rifampin does this
which drugs accumulate in macrophages(phagocytic cells)?fluroquinolones, rifampin ((the DNA and RNA ones! flo will put a rif in your macrophage collection)
which drug affects the retina in cats?flouroquinolones (also joint arthropathy--- flo stabs your knees and then her cats eyes)
which drug should you not give to animals with seizures, and why?FLOUROQUINOLONES because they dec GABA which inc CNS excitement--> seizures (FLO will give you a seizure with how annoying she is...and stabby)
Methenamine is used for what, and what should you know?used for UTIs (urinary antiseptic) requires acidic pH in renal tubule to release the formayldehyde. then meth broken down to release the drug....since it needs an acidic urine, DONT GIVE WITH SULFONAMDES because this will trigger them to cause major crystals (meth will make you pee a lot)
what is carbadox used for? side effects?used as a growth promoter in swine, prophy for enteric infections in swine. if conc exceeds in feed, aldosterone goes down! (will cause hypoaldosterinosm)
polymyxin/polystine work how? admin? can combine with? special traits?cell membrane (affects permeation process). Admin usually topically. can combine with sulfas. polymyxin binds with endotoxins of g- bact (replacing the membrane with sulfus would be very effective. Mixing in toxins will not even work bc polymyxin kills them)
g- endotoxin binding drug is?POLYMYXIN B
metronidazole--> used for what? tox?antiprotozoal and obligate anaerobic infections. highly carcinogenic.
what are the two lincosamides?lincomycin and clindamycin
what is clindamycins spectrum? what is it used against? what are its kinetics?specific in spectrum, effective against anaerobic and toxoplasma gondii. also more lipid soluable. can permeate BBB
abx which can fight toxoplasma gondii?CLINDAMYCIN (aunt linda hangs out with ghandi)
cna get into the CNS? (2)clindalmycin can cross BBB, chloramphenicol can get into CNS bc highly lipid soluable (aunt linda clamping on the brain)
what are the macrolides?Tilmicosin, Tylosin, tiamulin, Azithromycin, Clarithromycin, Erythromycin (mac will kill horses till his heart stops, camp with blood, and a girl named clair will be with him for just a few packs)
which drug is good for tx mycoplasma, and which group does it belong to?tylosin (and it's a macrolide) ...also this is the one fatal in horses. SO, can treat a COWS PINK EYE but dont you dare give it to the horses
which macrolide is type 3?AZITHROMYCIN is type 3, so has PAE (post antibiotic effect) which means it lasts longer in the host
how do you know if its a fluoro?has flox in it
when shouldnt you give enrofloxacin?with diary products or antiacids! remember, it's a fluoro and fluoros and tetras chelate cations (remember that flo is lactose intolerant and tetras will ruin your teeth)
what is the MOA of metronidazole?MOA- undergoes reduction in cell mitochondria and incorporated into structure and inhibits replication processes
most abx are type 2... what are the type 1 and 3s?(1) aminoglycosides (bc they have the PAE bc they irreversibly bind), and fluoroquin and metroni (bc they affect DNA) (3) tetracyclines and azithromycins

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