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Pharm Elective F-N

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dawale's version from 2017-08-04 04:13

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fentanylOpioid – sedation, anesthetic binds to various opioid receptors, producing analgesia and sedation Use: analgesia (pre-op), general anesthesia, pain (post-op)," "Preg MAO inhibitors" Addiction, abuse, respiratory depression, CYP450 3A4 interactions,
fingolimodMS; sphinosine-1-pi R modulator. decreasing autoimmune rxn AE Common: URI, HA, fatigue. Rare: skin ca, fatal infetions, bradycardia, hemorrhaging focal encephalitis (brain inflammation w bleeding). Fatal: brain hhv infx, a case of zoster. Progressive multifocal leukoencephalopathy and macular edema
flecainideClass I-C antiarrhythmic agent. Tachyarrhymias, paroxsysmal afib and supraventr tachycardia, WPW and ventricular tachycardia. Na channel block in heart, slows AP upstroke and prolongation of cardiac AP. AE Cardiac, pulm toxicity. Drug-drug: Alcohol: decreased DV fxn. Amiodarone and quinidine: inhibit CYP 2D6 increase levels. Cimetidine increases flecainide levels by 30% / half life by 10%. Digoxin increases levels. Paroxetine: increased both drugs effect.
fludrocortisoneadded to hydrocortisone in adrenal insufficiency. first line: orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS). Hypotension. MOA Mineralcorticoid w minor glucocorticoid effect AE Common: HTN, edema, heart failure, increased sodium/ low blood potassium, low immune system, cataracts, mm weakness, mood changes. Intx: other mineralcorticoids, high doses other GC
fluocinonide-nasal sprayallergic rhinitis, corticosteroid AE systemic absorption over time, increase in infections bc local steroid dec. immune activity.
gentamycin drops
glatiramer acetateSQ for MS. Resembles myelin basic protein, known to shift T cells from proinflam T cells from proinflam Th1 c to reg Th2 that suppress inflam response. Injection site rxn in 30% users, aches, fever, chills 10%. Flushing, SOB, anxiety, tachycardia from IV injection~30 min if hit v. Lipoatrophy at injection site
glucagonEndocrine: Hypoglycemia. opposite insulin. hypoglycemia, beta blocker OD, CCB OD, anaphylaxis in those who do not improve w epinephrine. GI spasms/esophageal spasm. CI pheochromocytomas and INSULINOMAS
Haemophilus influenzae (Hib) vaccine
human chorionic gonadotropinFemales: induce final maturation of follicle and ovulation. Males: stim testosterone prod, hypogonadism, fertility tx. Off label for weight loss, to restore testicular size in anabolic steroid use. Pituitary analog is LH. AE: increased ectopic pregnancy, androgen dep tumors, potential pituitary LH suppression.
hydralazineFor HTN, CHF. AE HA, tachycardia, palpitations, flushing hypotension, anginal sx. Prolonged tx: drug induced lupus. Intensifies any HTN/TCA drug, hypotension.
hyoscyamineScopolamine. Motion sickness. Belladonna alkaloid.
irbesartanARB. HTN and Diabetic Nepropathy in DM2 patients.
imiquimodTopical for genital warts, BCC, AK. Immune activator. AE local inflammation, flu like sx. C/I for those on transplant medications.
indomethacinNon specific NSAID for severe pain and inflammation (autoimmune, etc.) AE: Renal Toxicity is common, marrow failure. Increases Li levels. Hyperkalemia with K+ sparing drugs.
infliximabImmune suppression: TNF inhibitor (monoclonal Ab). For Crohn's, UC, Psoriasis, Psor Arth, AS, RA.
isosorbide mononitrateAngina (nitrate). AE: HA, fatigue, sleep disturbance. Do not administer with PDE5 inhibitors, can result in MI/syncope and life threatening hypotension.
ivermectinParasites, lice, scabies, filariasis, rosacea. AE: skin/eye itching and burning. Use caution with CNS depressants. Interacts with GABAa drugs (BBB).
ketoconazole
ketorolacNSAID. Non selective. Toradol.
lamotrigineLamictal. MoA unknown
Uses: Epilepsy, Bipolar I(to prolong time between mood changes)
SE: Serious skin rashes; Multi-organ hypersensitivity reactions and organ; Blood dyscrasias; Suicidal behavior and ideation; Aseptic meningitis; Withdrawal seizures; Status epilepticus; Sudden unexplained death in epilepsy
Pregnancy category C
leuprolideCA: PR, BR, endometriosis, fibroids, early puberty. GnRH agonist, interrupts normal pulsatile stimulation, desensitizes GnRH receptors, therefore downregulating secretion of LH and FSH. Leads to reduction in E2 and T, hypogonadism. AE hot flashes, night sweats, vaginal sx, lots of other AE.
levofloxacinFluoroquinolone Abx.
lidocaineShort acting amide anesthetic.
losartanARB. HTN and Diabetic Nepropathy in DM2 patients.
meclizine-OTCMotion sickness. Non selective H2 blocker. AE sedation, interactions with other CNS sedatives and H1 drugs (additive)
megestrol acetateLow dose: OCP with Eth-E2. High dose: BR and END CA. 17a-OH progestin. AE weight gain, N/V, edema, nightmares, SOB, breakthrough bleeding.
memantineFirst of its kind
Modest effect in moderate to severe Alzheimer’s
Acts on glutamatergic system, blocks NMDA-type glutamate receptors (glutamatergic exicitotoxicity)
Also used in dementia with Lewy bodies
SE: confusion, dizziness, drowsiness, headache, insomnia, agitation, hallucinations; vomiting, anxiety, hypertonia, cystitis, increased libido.
mesalazine (mesalamine)IBD. Aminosalicylate anti-inflammatory drug. AE KD failure, GI upset.
methimazoleEndocrine: Thyroid: for hyperthyroidism. Thyroid blocking, for thyrotoxicosis.
methocarbamolMuscle relaxant. Methocarbamol is the carbamate of guaifenesin; may turn urine black, blue, or green.
metoprololB1 blocker. decreases cardiac output, renin. Angina, HTN AE FATIGUE, drowsiness, vertigo, dizziness, bradycardia, bronchospasm, CHF
memorize

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