what is MAO-A (inhibitor) and what is it responsible for?
enzyme to break down NTs n stuff. A= CENTRAL+PERIPHERAL and deals with SEROTONIN, NOREPI, and EPI (NES traveled far and wide)
what is MAO-B (inhibitor) and what is it responsible for?
enzyme to break down NTs and stuff. B= CENTRAL ONLY. NOREPI AND DOPAMNIE. (I want you to B the CENTER of my world, NOR said. cuz ur DOPe)
what might cause serotonin syndrome, and explain the syndrome.
MAO-B might (b/c centrally acting) and it causes hypertension, hyperthermia, metabolic ACIDosis, rhabdomyolysis
what kinda drug is selegiline? what is it used for? side effects?
selective irreversible MAO-B inhibitor. (Gil B the CENTER of my world because he DOPE) treat dementia, fear and phobias, pituitary dependent hyperadrenocorticism. Side effects= hyperactivity and stereotypic b/h
SNRI/Tricyclics have affinity for what? adverse effects? metabolism? use for in dogs? cats?
have steroid ring structure, analogues of testosterone (*INC mm strength, INC positive nitrogen balance, INC retention of ions (Na, Ca, K, P), INC myelopoiesis- blood cell production )
indications of anabolic steroids?
for catabolic diseases-- mm wasting dz, chronic degenerative dz, aplastic anemia, chronic anemia, lymphoma
hypernatremia (inc water retention, lead to myocardial infarction) , hypercalcemia, hyperkalemia, hyperphosphatemia ---> probs in rate and rhythem of heart. also azotemia (too many nitrogenous substances such as urea, createnine)
why do they cause repro problems?
Testosterone analogue- affect sperm production, estrus suppression in female
*contraindications of anabolic steroids?
no animals with *prostrate hypertrophy, and preg animals (bc teratogenic) no food animals, no reproducing animals (dec sperm quality and ertrus)
azotemia, hyper calcemia, P and K, Na & h2o retention, hepatopathy (cats), repro abnormalities (oligospermia, estrus supression). Contras- food animals, pregers, begnin prostatic hyperthrophy in dogs, breeding stallions.
Nandrolone is used in which animals? to tx what?
dogs and cats. chronic anemia and aplastic anemia. (got blood? NAN to speak of)
Boldenone undecyclenate used for?
long acting anabolic steroid for HORSES. increase appetite and weight gain, improve nitrogen balance, reduce overexertion during exercise. can cause aggressiveness and reduced sperm count (horses are as big as boulders)
Diethyl stilbesterol used for? precautions?
Management of estrogen-responsive urinary incontinence (spayed female) and Perianal gland adenoma (intact male dogs). *carcinogenic in nature
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