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Pharm - Antimycobacterial

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dogolufi's version from 2017-09-18 03:52

Section 1

Question Answer
What are the 1st line TB drugsisoniazid, rifampin, ethambutol, streptomycin, pyrazinamide
What are teh 2nd line TB drugsethionamide, ofloxacin, ciprofloxacin
Positive PPD test requires what?6-9 months of isoniazid prophylaxis therapy
Which 1st line TB drug is INTRAcellular only?Pyrazinamide
Which 2nd line TB drug is EXTRA cellular only?Streptomycin
What is the most common anti-TB therapy toxicity?hepatitis
What regimen is best for penetration of the meninges?pyrazinamide + ethionamide + isoniazid
Dont use isoniazid w/ what other drug?phenytoin
What is isoniazid commonly combined w/pyridoxine - B6
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Section 2

Question Answer
which 1st line TB drug blocks arabinosyl transferaseethambutol
Which of the TB drugs is contra-indicated in children due to loss of visual acuity and red-green color blindness?ethambutol
Which 1st line TB drg is an irreversible inhibitor of 30S subunit?streptomycin
Which of the TB drugs is an aminoglycoside?streptomycin
Which 1st line TB drug only penetrates into CNS when the meninges are inflammed?ethambutol
What are the side effects of rifampin?1) orange color to tear 2) hepatitis 3) thrombocytopenia 4) rash
The 1st line TB drug is a nicotine analogue w/ unknown molecular target is rapidly taken up by what?pyrazinamide - rapidly taken up by macrophages
Which TB drug binds the b-SU of DNA-dep RNA polymerase rifampin
If a patient is HIV +, what drug is C.I? What should be used instead?Rifampin is CI; use Rifabutin in lieu
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Section 3

Question Answer
PAS blocksfolate synthesis
Cipro and Ofloxacin blockdna gyrase
What is used to treat leprosy?Dapsone and Rifampin
What is an anti-inflammatory that acts to prevent erythema nodosum leprosumclofazimine
Drg cuases red black skin discoloration and eosinophilc enteritisclofazimine
blocks the proton pump of ATP synthaseR207910
effective against latent TBPA-824
causes build up of NO by bindind an aromatic nitro group on FAD cofactorPA-824
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Section 4

Question Answer
Where does leprosy localize?peripheral nervees, skin, mucous membranes and colder parts of body
What is the MOA of dapsone?disrupts folate synthesis
where is pyrazinamide effect?acidic pH of the phagolysosomes
Which TB drug is affected by fast/slow acetylators?Isoniazid
What are the side effects of isoniazid?Neurotox, hepatotoxicity and lupus
Isoniazid decreases the synthesis of?mycolic acids
What is required for isoniazid to work?catalase-peroxidase
What can be used for MAC prophylaxis?azithromycin
T/F: dapsone is safe to admin over a period of years?true
Ethionamide blocks what?mycolic acid synthesis
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Section 5

Question Answer
What atre the rapidly growing mycobacteria?M. fortuitum and M chelonae
Isoniazid and Ethambutol both inhibitcell wall synthesis
Rifampin and Rifabutin both inhibitRNA polymerase
What inhibits protein synthesisaminoglycosides, clarithromycin, azithromycin
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