Pharm- ANS

ajkim1's version from 2015-06-18 03:19


Question Answer
CholinergicParasympathetic NS
Uses Ach both pre and post synapticallyParasympathetic NS
Depolarizes the craniosacral systemParasympathetic NS
Uses cGMP as a second messengerParasympathetic NS
Most receptors are muscarinic with fewer nicotinic receptorsParasympathetic NS
The fewer nicotinic receptors of the Parasympathetic NS are located at the _____ and _____NMJ; ganglia
AdrenergicSympathetic NS
Uses Ach presynaptically and NE postsynapticallySympathetic NS
Depolarizes the thoracolumbar systemSympathetic NS
Uses cAMP as a second messengerSympathetic NS
Most receptors are nicotinic with fewer muscarinic receptorsSympathetic NS
The fewer muscarinic receptors of the Sympathetic NS are located at the _____ and _____Sweat glands; adrenal medulla
Muscarinic receptors of the Parasympathetic NS (3)M1, M1, M3
M1 of the Parasympathetic NSCNS/ENS (brain)
M2 of the Parasympathetic NSHeart
Increases exocrine gland secretion in Parasympathetic NSM3
Increases gut motility in Parasympathetic NSM3
Miosis via pupillary sphincter in Parasympathetic NSM3
Accomodation via ciliary in Parasympathetic NSM3
Bronchoconstriction in Parasympathetic NSM3
Bladder constriction in Parasympathetic NSM3
Tx for post op and neurogenic ileus and urinary retentionBethanachol
Tx for glaucoma, pupillary contraction, relief of IOP, and post op urinary retentionCarbechol
Induces bronchospasm used in asthma challenge testMethacholine
Cystic fibrosis sweat testPilocarpine
Prevent degradation of Ach by increasing endogenous AchAnti Ach Esterases
Diagnostic test for myasthenia gravisEdrophonium
Short-acting tx for myasthenia gravis, ileus, urinary retention, reversal of NMJ blockage, doesn't cross BBBNeostigmine
Long-acting tx for myasthenia gravis, ileus, urinary retention, reversal of NMJ blockage, doesn't cross BBBPyridostigmine
Tx for myasthenia gravis that will cross BBB, also tx for glaucoma and atropine ODPhysostigmine
Tx for glaucomaEcthiophate
Lipid-soluble tx for Alzheimer's disease (2)Donepezil or Tacrine
Tx for anti-cholinesterase organophosphate poisoningAtropine with Pralidoxime
Symptoms of anti-cholinesterase poisoningDUMB BELSS (diarrhea, urination, miosis, bronchoconstriction, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, salivation)
Antagonize M3Anti Ach
Decrease in exocrine gland secretionsM3 antagonist
Decrease gut motilityM3 antagonist
Mydriasis or no miosisM3 antagonist
Cycloplegia or no accomodationM3 antagonist
BronchodilationM3 antagonist
Bladder relaxationM3 antagonist
Causes mydriasis with cyclopegia, management of Anti-AchE poisoningAtropine
Lipid soluble CNS entry for Parkinson's, and EPS symptoms due to antipsychoticsBenztropine or Trihexyphenidyl
Muscarinic antagonist with a higher affinity for M1 receptorsBenztropine or Trihexyphenidyl
Safe to use in asthma and COPDIpratopium
Reduce urgency in mild cystitis (urge to pee) and reduce bladder spasms to pee lessGlycopryrrulate or Oxybutinin
Motion sickness cureScopolamine
Peptic ulcer treatmentMethscopolamine or Pirenzepine or Propantheline
Receptor for vasoconstriction, sphincter constriction (urinary return), mydriasis via radial (dilator muscle), bronchodilationAlpha 1 receptor
Suffux for alpha 1 agonists-Rine
Epinephrine or norepinephrineAlpha 1 agonist
Nasal decongestant treatmentEphedrine
Cold relief treatmentPseudoephedrine
Tx for incontinence (pee urgency) in the elderlyEphedrine or pseudoephedrine
Tx for neurogenic shock and nasal decongestion, causes pupillary dilation, vasoconstrictionPhenylephrine
Alpha 1 agonist that causes decreased production of aqueous humor and vasoconstriction, treats hypotension, asthma, anaphylaxis, open angle glaucomaEpinephrine
Alpha 1 agonist that treats hypotension by decreasing renal blood flowNorepinephrine
Alpha 1 antagonist that diagnoses pheochromocytoma, treats patients on MAOi that ate tyraminePhentolamine
Rare tumor of adrenal gland tissue that results in the release of too much epi and NEPheochomocytoma
Alpha 1 antagonist that treats pheochromocytomaPhenoxybenzamine
Alpha 1 antagonist that treats impotenceYohimbine
Alpha 1 antagonist that treats HTN but associated with first dose syncopePrazocine
Alpha 1 antagonist that is first line for BPH, also for HTNTerazocin or Doxazocin
Alpha 1 antagonist that treats BPH with the least SETamulosin
Receptor that decreases NE and insulin release, and promotes platelet aggregationAlpha 2 receptor
Alpha 2 agonist that treats HTN and psychosis, associated with rebound HTNClonidine
Alpha 2 agonist that treats HTN and safe in pregnancyAlpha-Methyl Dopa
SE of Alpha-Methyl DopaCoombs and hemolytic anemia
Alpha 2 antagonist that treats depressionMirtazapine
SE of MirtazapineIncreased appetite, serum cholesterol, and sedation
Receptor that increases heart rate, increases contractility, promotes glucagon and renin release, increases lipolysisBeta 1 receptor
Receptor that increases contractility, vasodilation, uterine relaxation, bronchodilation, increases insulin secretionBeta 2 receptor
Beta 1 agonist that treats congestive heart failureDobutamine
Beta 1 agonist that treats bronchospasm, heart block, and bradyarrhythmiasIsoproterenol
SE of IsoproterenolFlushing, angina, arrhythmias
Agents mainly used for asthmaBeta 2 agonists
Beta 2 agonist with a short half life used for asthmaAlbuterol
Beta 2 agonist with a short half life used for asthma and premature labor treatmentTerbutaline
Beta 2 agonist that for premature labor treatmentRitodrine
Beta 2 agonist that is a long term treatment for asthmaSalmeterol
Suffix for beta antagonists-Olol
Beta antagonist that has a long half life, used for thyroid storm to prevent peripheral T4-T3 conversionPropanolol
Beta antagonist with a short half lifeEsmolol
Beta antagonists (3) with partial beta agonist effects that are safe to give to patients with DM, COPD, or asthmaAcebutolol, Atenolol, Pindolol
Beta antagonists (2) with A1 antagonistic activity used for HTN emergenciesLabetalol and Carvedilol
Best drug for HTN emergenciesSodium Nitroprusside
Beta antagonist that treats liver failure and decreases variceal bleedingNadalol
Beta antagonists (2) that treats open angle glaucoma by decreasing secretion of aqueous humorTimolol or Butexalol
Beta antagonists that decrease post MI mortalityCarvedilol and Metoprolol
Beta antagonist that increases the QT intervalSotolol