Pharm 2 - Cardio

gsafsaf's version from 2015-05-23 19:07

Anti-arrhythmics 1

Question Answer
Class I anti-arrhythmics Na+ channel blockers - decrease slope of phase 0 (depolarization) of ventricular myocytes
Class II anti-arrhythmics ß-blockers - flatten out phase 4 of pacemaker cells - slows heart in general
Class III anti-arrhythmics K+ channel blockers - slow down phase 3 of ventricular myocytes - elongating effective refractory period; increase action potential duration
Class IV anti-arrhythmics Ca2+ channel blockers - decrease the slope of phase 0 of pacemaker cells - elongating effective refractory period - decrease in conduction of AV nodal cells
Class IAdisopyramide, quinidine, procainamide "double quarter pounder"
Class IBLidocaine, mexiletine, tocainide "mayo lettuce tomato"
Class ICFlecainide, propafenone "fries please"
Class IAIncrease action potential duration, effective refractory period, and QT interval
Side effect of cinchonismQuinidine
Side effect of SLE-like syndromeProcainamide
Commonly used after MILidocaine
Class IBMost used of Class I
Class ICCan by PRO-arrhythmic esp. in post-MI state
Class IRaise the threshold potential of cardiac fast response tissues (cardiomyocytes)
Class IVRaise the threshold potential of cardiac slow response tissues (SA + AV nodes)
VerapimilClass IV Ca2+ channel blocker - In addition to decreasing Ca2+ influx during phase 0 and the latter part of phase 4, it can decrease the amount of intracellular Ca2+ available for excitation-contration coupling within cardiomyocytes, reducing myocardial contractility - can be harmful in pts w impaired ventricular function
Class IBshorten the action potential; dissociate from the Na+ channel more rapidly than other drugs in their class
Class IA + IIIprolong repolarization + increase refractory period

Anti-arrhythmics 2

Question Answer
Class IAQuinidine
Class IAProcainamide
Class IADisopyramide
Class IBLidocaine
Class IBMexiletine
Class IBTocainide
Class ICFlecainide
Class ICPropafenone
Class IIPropanolol
Class IIMetoprolol
Class IIIAmiadarone
Class IIISotolol
Class IVDiltiazem
Class IVVerapamil

Lipid lowering agents

Question Answer
StatinsHigh LDL
StatinsS/E of hepatitis, myopathy
NiacinLow HDL
NiacinS/E of cutaneous vasodilation, hyperglycemia/acanthuses nigricans, hyperuricemia/gout, hepatitis
Fibric acid derivativesHigh TG
Fibric acid derivativesS/E of gallstones, myopathy
Bile acid-binding resinsHigh LDL
Bile acid-binding resinsS/E of GI upset, hypertriglyceridemia, malabsorption