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Pharm 1 - OPIOID CHARTS

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drraythe's version from 2015-06-13 14:18

Functional Aspects Chart (OPIOIDS)

Question Answer
What are the three receptors that opioids work on? How do they affect the receptors?Mu, Delta, Kappa. They agonize them.
Which receptor for opioids is linked w/ physical dependence?Mu (& Kappa)
What is the benefit of the Mu receptor? The disadvantages?Mu is the receptor for the strongest response, however, you will see the most respiratory depression & constipation
Which receptor has the strongest effect on analgesia?Mu
Which receptor has the strongest effect on respiratory depression?Mu
Which receptor has the strongest effect on euphoria?Mu
Which receptor has the strongest effect on dysphoria?Kappa
Which receptor has the strongest effect on physical dependence?Mu
Which receptor has the strongest effect on pupil constriction?Mu
Which receptor has the strongest effect on GI motility?Mu or Delta are equal (butt MuD)
Which receptor has the strongest effect on sedation?Mu or Kappa are equal (someone sedated Michael Kors)
Which receptor has no effect on respiratory depression?Kappa
Which receptor has no effect on pupil constriction?Delta
Which receptor has the least effect on GI motility?Kappa
Which receptor has no effect on euphoria?Delta & Kappa
Which receptor has no effect on dysphoria?Mu & Delta
Which receptor has no effect on sedation?Delta
Which receptor has no physical dependence linked to it?Delta
What is the only receptor which has an effect on supraspinal analgesia?Mu
What are the areas that the Mu receptor affects?Everything but dysphoria
What are the areas that the Delta receptor affects?Spinal analgesia, resp depression, GI motility (Delta RiGS the ticket system, talk about a stab in the back (spine) )
What are the areas that the Kappa receptor affects?Spinal & peripheral analgesia, pupil constriction, reduced GI motility, dysphoria, sedation, & physical dependence (Kappa digests pretty polly pocket going summer swimming)
memorize

Selectivity of Opioids for Receptor Subtypes Chart (OPIOIDS)

Question Answer
What are the endogenous peptide opioids? (4)(-in's) Beta-endorphins, leu-enkephalin, met-enkephalin, dynorphin
What does the suffix "-one" indicate?works on Mu receptor only, unless it is an antagonist (those have x's)
What are the pure agonists opioids? (8)(-ine's & -one's except for one.) codeine, morphine, hydromorphone, oxymorphone, methadone, meperidine, ethorphine, fentanyl (addictive crap you hear about on the news, plus MEeatingPEARs (also addictive) & Ethorphine, E for elephants)
What are the partial/mixed agonist opioids? (5)(-ine's except for one.) pentazocine, nalbuphine, nalorphine, buprenorphine, butorphanol (5 nalnal butts when cat is trippin)
What are the antagonists for opioids (reverse effects) (2)(both have an x to x-out opioids) naloxone, naltrexone
Which receptors are Beta-endorphines non/selective for?Equally very strong selection for Mu, Delta, & Kappa
Which receptors are leu-enkephalin non/selective for?Strongest Delta, no Kappa
Which receptors are met-enkephalin non/selective for?Strongest Delta, no Kappa (I met him on a Delta flight)
Which receptors are dynorphin non/selective for?Strong Kappa, weak Delta
Which receptors are codeine non/selective for?Strong Mu
Which receptors are morphine non/selective for?Strong Mu
Which receptors are hydromorphone non/selective for?ONLY Mu
Which receptors are oxymorphone non/selective for?ONLY Mu
Which receptors are methadone non/selective for?ONLY Mu
Which receptors are meperidine non/selective for?Strong Mu
Which receptors are ethorphine non/selective for?All three equally very strong
Which receptors are fentanyl non/selective for?Strong Mu, no Kappa
Which receptors are pentazocine non/selective for?ANTAGONIZE Mu, strongest is Kappa (devil worshipers in the KKK will kill kittens)
Which receptors are nalbuphine non/selective for?ANTAGONIZE Mu, weak Delta, partial agonist Kappa
Which receptors are nalorphine non/selective for?ANTAGONIZE Mu, no Delta, partial agonist Kappa
Which receptors are buprenorphine non/selective for?Partial strong Mu agonist, no Delta, ANTAGONIZE Kappa (suboxone doesnt give you pain, but it wont let you fully feel pleasure)
Which receptors are butorphanol non/selective for?Partial strong Mu agonist, no Delta, strong Kappa
Which receptors are naloxone non/selective for?ANTAGONIST. Strongest antagonist of Mu
Which receptors are naltrexone non/selective for?ANTAGONIST. Strongest antagonist of Mu & Kappa
memorize

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