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PG analogues

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nelso418's version from 2017-02-24 09:23

Section

Question Answer
DinoprostonePGE2 - Uterine Contraction
CarboprostPGF2alpha - Uterine Contraction - 15 methyl
MisoprostolPGE1 - NSAID ulcer protection and uterine contraction - methyl-ester (OH is moved to 16)
LatanoprostPGF2alpha - Glaucoma
TravoprostPGF2alpha - Glaucoma
BimatoprostPGF2alpha - Glaucoma
UnoprostonePGF2alpha - Glaucoma
EpoprostenolPGI2 - PAH - short half life, continuous IV infusion
IloprostPGI2 - PAH
TreprostinilPGI2 - PAH - longest half life in class
AlprostadilPGE1 - Patent Ductus Arteriosus and ED
EnprostilPGE2 - more selective - used to prevent NSAID ulcers
ArthrotecDiclofenac + Misoprostol (NSAID + GI ulcer protection)
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