| Class | Drugs | Uses |
|---|
| muscarinic receptor agonists | acetylcholine, carbamylcholine, bethanecol, pilocarpine | research; OA glaucoma; gastrointestinal stasis, stimulate urination; OA glaucoma, emergency treatment of CA glaucoma, stimulate salvation, treatment of muscarinic antagonist overdose |
| muscarinic receptor antagonists | atropine, scopolamine, quaternary amines (methylatropine) | GENERAL antispasmadics(in intestine and colon); mydriasis; motion sickness(CNS effects); urge incontinence and antispasmatics |
| ganglionic stimulants/nicotinic receptor agonists | nicotine | insectisides, smoking cessation, experimental for ulcerative colitis and certain neuralogic disorders |
| ganglionic blockers/nicotinic antagonists | hexamethonium, mecamylamine | essential hypertension, hypertensive crisis, test for pheochromocytoma |
| non-depolarizing neuromuscular blockers | d-tubocurarine | production of skeletal muscle relacation during surgery, for controlled ventilation during surgery, facilitate orthopedic procedures (bone setting), electroconvulsive shock(prevent injury), to permit forced ventilation in ventilatory failure |
| depolarizing neuromuscular bockers | succinylcholine | facilitate tracheal intubation |
| cholinesterase inhibitors(anticholinesterases) | endrophonium, neostigmine and pyridostigmine, physostigmine, donepezil, echothiophate(ir) | diagnosis of myasthenia gravis; treatment of mysathenia gravis, reverse nondepol. NM blockade; OA glaucoma, Alzheimer's, antimuscarinic poisoning; Alzheimer's; OA glaucoma |
| cholinesterase reactivator | pralidoxime(2-PAM) | for organophosphate anticholinesterase intoxication |
| Drugs/toxins inhibiting Neuromuscular Transmission or Muscle Contraction | Dantrolene, Botulinum toxins(7) | malignant hyperthermia, neuroleptic malignant syndrome, spasticity; local injection into muscles to cause weakness or reduce spasm |
| Nonselective adrenergic receptor agonists(alpha and beta) | Norepinephrine and Epinephrine | local vasoconstriction, nose, throat and larynx surgery, slow abs. or local anesthetics, open angle glaucoma, cardiovascular shock (NE), cardiac arrest(EP), bronchial asthma(OTC), anaphylactic shock (EP) |
| alpha1 receptor selective agonists | phenylepherine, axymetazoline, tetrahydrozoline | mydriatic agent, cardiovascular shock, slow abs. of local anesthetics, nasal and ocular decongestion; nasal and ocular decongestion |
| alpha2 receptor selective agonists | clonidine, methyldopa | hypertension, in select drugs reduce anxiety symptoms, analgesia, sedative/hypnotic effect, anesthesia(vet) |
| nonselective beta receptor agonists | isoproterenol | emergency cardiostimulant, brochodilator in asthma |
| beta2 receptor selective agonists | albuterol, terbutaline, salmeterol; ritodrine | asthma; uterine relaxation in premature labor |
| indirectly acting sympathomimetic amines/ those with mixed indirect and direct actions | Tyramine, Ephedrine, Pseudoephedrine, Amphetamine, methamphetamine | "cheese effect" causes inc. NE when taking MAOI; bronchodilation in asthma, nasal decongestion; nasal decong.; appetite suppression, ADHD, narcolepsy; rec drug |
| non-selective alpha receptor antagonists | phenoxybenzamine(haloalkylamine), phentolamine(imidazoline) | epinephrine reversal, pheochromocytoma, benign prostatic hypertrophy, periphereal vascular disease; acute control of hypertension in pheochromocytoma, acute control of hypertensive emergencies, prevention of dermal necrosis, treatment of impotence via injection |
| alpha receptor selective antagonists | prozasin, tamsulosin(alpha 1A) | essential hypertension, CHF, peripheral vascular disease, hemorrhagic shock, benign prostatic hypertrophy; benign prostatic hypertrophy |
| non-selective beta receptor antagonists | propranolol | hypertension, prevention of cardiac dysrhythmias, CHF, cardioprotection following MI, angina pectoris, hyperthyroidism, OA glaucoma, prevention of migraines, treatment of anxiety symptoms, essential tremor and drug-induced tremor |
| beta1 receptor selective antagonists | atenolol | similar to non-selective beta antagonists but preferred for patients w/ diabetes, peripheral vascular disease, bronchospasm |
| beta receptor selective antagonists/agents with intrinsic sympathomimetic activity (ISA) | pindolol | clinical significance controversial |
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