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Pentose Phosphate Pathway

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Updated 2009-02-15 23:08

Pentose Phosphate Pathway

Oxidative Branch
ReactionEnzyme
Glucose 6-Phosphate + NADP+ ->
6-Phosphoglucono-δ-Lactone + NADPH + H+
Glucose 6-Phophate Dehydrogenase
6-Phosphoglucono-δ-Lactone + H2O ->
6-Phosphogluconate + H+
Lactonase
6-Phosphogluconate + NADP+ ->
Ribulose 5-Phosphate + CO2 + NADPH
6-Phosphogluconate Dehydrogenase
memorize

 

Non-Oxidative Branch
ReactionEnzyme
Ribulose 5-Phosphate <=> Ribose 5-PhosphatePhosphopentose Isomerase
Ribulose 5-Phosphate <=> Xylulose 5-PhosphatePhosphopentose Epimerase
Xylulose 5-Phosphate + Ribose 5-Phosphate <=>
Sedoheptulose 7-Phosphate +
Glyceraldehyde 3-Phosphate
Transketolase
Sedoheptulose 7-Phosphate +
Glyceraldehyde 3-Phosphate <=>
Fructose 6-Phosphate + Erythrose 4-Phosphate
Transaldolase
Xylulose 5-Phosphate + Erythrose 4-Phosphate <=>
Fructose 6-Phosphate + Glyceraldehyde 3-Phosphate
Transketolase
memorize

 

Reference: p.431 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).