shevyatiwari's version from 2015-04-18 02:32


Question Answer
Pen G is given POF, IV (benzylpenicillin)
Pen V is given POT, phenoxymethylpenicillin
Pen G is more stable in the presence of gastric acid and better absorbed from the GIT than Pen VF, Pen V is better
Pencillins are pregnancy category...B
Penicillins are excreted in breast milkT
Sensitisation has been reported in infants associated with amoxycillin use in nursing mothersF, ampicillin
Pen G, Pen V are isoxazolylF, first generation natural penicillins
Pen V and Pen G are equally potent against GP cocci, GN cocci and anaerobesF, Pen V is less potent but range of activity is the same
MSSA is susceptible to Pen VF
Isoxazolyl are first generation penicillins which have anti pseudomonas activityF, are resistant to penicillinase
Aminopenicillins are second generations which extend spectrum of activity to GNB'sT
Carboxypenicillins include ticarcillin are fourth generationF, third
Uriedopenicillins are fourth generation and include piperacillinT
Third and fourth generations exhibit antipsuedomonal activityT
The antipseudomonal activity of third and fourth generation penicillins is increased with an aminoglycosideT
B lactamases can cause any of the first to fourth generations to become ineffectivT
Nafacillin exhibits favourable pharmacokinetic propertiesF, dicloxacilin
Dicloxacillin can be given in doses of up to 2g/dayF, 4g/day
Dicloxacillin should be given with foodF, 1 hour before or after a meal
Amoxycillin should be given fastingF, can be given with food
Ampicillin is superior to amoxycillinF
Most penicillins have half lives of 2-4 hoursF, <1.5 hours
All penicillins are excreted renallyF, naf, ox, pip are excreted in hepatobiliary system
Isoxazolyl penicillins show good S pyogenes coverT
Pen V is the most common b lactam in hypersensitivity reactionsF, amoxycillin
Ampicillin if given to those with lymphocytic leukaemia, in combination with allopurinol or in those with EBV causes a reaction that precludes from further useF
A reaction if ampicillin is given with LL, EBV or with allopurinol is seen within 7-10 days of initiationT
A reaction if ampicillin is given with LL, EBV or with allopurinol goes away in 7-10 daysF, 7 days
All penicillins cross reactT
If a patient has a true allergy to penicillin they will probably have one to cephalosporinsT
Isoxazolyl's have the highest incidence of allergic reactionsF, aminopenicilins
GI effects and C difficile can occurT
Yogurt or lactobacillus may be helpfulT
Haemolytic anaemia, neutropenia, platelet dysfunction, seizures and electrolyte disturbances occur with high doses of PO formulationsF, IV
Shore nails can be seen after aminopenicillinsF, dicloxacillin
Photo-onycholysis seen after dicloxacillinF, oxacillin
Cholestasis is commonF
Local reactions including phlebitis, myositis and vasospasm are common post PO F, IM/IV
Probenicid -> prolonged renal excretionT
Warfarin -> altered anticoagulation effectsT
B haemolytic strep should be treated for 1 weekF, 10 days
Scarlet fever should be treated for 10 days with Pen V or one dose of Pen GT
Latent syphilis of > 1 year requires 1 IM pen GF, that is primary and secondary syphilis. Tertiary requires 3 weekly injections
Probenicid can be coadministered with ampicilin for H influenza if higher blood levels are neededT

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