Penicillin - PHARM2

lunalovegood's version from 2016-09-20 00:31


Question Answer
T/F - Beta Lactam antibiotics have the widest spectrum of antibiotic activity.T
Penicillin has 2 rings. ____ & ___thiazolidine & Beta-lactam
Name 2 PBPs (penillicin binding proteins)transpeptidase & carboxypeptidase
Bulky side chain help with...amidase inhibition
T/F - Beta lactamase inhibitors are suicide inhibitors. T
Prophylaxis for rheumatic fever or bacterial endocarditislong acting penicillin (procaine penicillin - 28 days)
Can you mix and match shit like Augmentin Sulbactam Amoxicillin Ampicillin?fuck no. follow the rules.
NSAID or Probenacid will ____ (increase/decrease) penicillin half life.increase (decreases renal excretion)
Does penicilloic acid have antibacterial properties?no
Does 6-aminopencicillanic acid have antibacterial properties?yes, some.
T/F - Common oral infections include orofacial abscesses, pulpal/periapical infections and ANUG.T
T/F - Staph aeurus and strep viridans cause lots of oral infections.T


Question Answer
No gram - activityMethicillin
Small gram - activityPenicillin G
Some Beta-lactamase resistance (staph)Methicillin (due to bulky side chains)
Injection, IV, IMPenicillin G
Only 20% absorbedPenicillin G
60% absorbed - most frequently used dental infection antibioticPenicillin V
Upsets GI quite a bitAmpicillin
_________ + Clavulonic Acid = AugmentinAmoxicillin
1. Penicillin G 2. Methicillin 3. Carbenicillin & Ticarcillin 4. _________ _________ & _________Penicillin V, Ampicillin, Amoxicillin
_____ + ________ = UnasynAmpicillin + Sulbactam
Ticarcillin + clavulanate = ___Timentin
Piperacillin + Tazobactam = ____Zosyn
Taken orally because relatively acid stablePenicillin V
Less GI upsetAmoxicillin
Pt is allergic to penicillin. Now what?Clindamycin or Erythromycin


Beta Lactamase Groups
Question Answer
Cephalosporinase not well inhibited by clavulonic acidGroup 1
Penicillinases, cepahlosporinases, and Beta lactamases that are inhibited by some Beta lactamase inhibitorsGroup 2
Metallo Beta lactamases that are poorly inhibited by almost all enzyme inhibitorsGroup 3
Penicillinases not inhibited by clavulonic acidGroup 4