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PCOM NSAIDs

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ayoung8764's version from 2016-01-30 00:59

Section 1

Question Answer
AspirinIrreversible COX
DifunisalCompetitive COX
AcetominophenInhibit COX only with low H2O2
IbuprofenCompetitive COX
NaproxenCompetitive COX/ X lysosomal enz/ X migration of leuk
KeterolacIntramuscular injection/ POTENT COX
TolmetinCompetitive COX
DiclofenacCompetitive COX/ Decrease free arach acid in leuk
PiroxicamCOX inhibitor/ X activity of neutrophils and hemostasis
PhenylbutazoneCompetitive COX
Indomethacin/SolindaCompetitive COX/ Decrease mobility of PMN leuk
Celecoxib/ rofecoxibSelective COX 2 only
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Section 2

Question Answer
Interfere with leukocytesNaproxen/Diclofenac/Piroxicam/Indomethacin
No in PregnancyIndomethacin/ Celecoxib/ Misoprostol
Supresses GI affectMisoprostol
Compete with warfarinDifunisal/ Piroxicam/ Phenylbutazone
P450 metabolizedAcetominophen/ Celecoxib
Taken off market b/c heart attacksRofecoxib
Interact with thyroxine and naproxenAspirin
Interfere with B BlockersIndomethacin
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Section 3

Question Answer
Not for inflammationAcetominophen
Not for plateletDifunisal/ Acetominophen/ Diclofenac/Phenylbutazone/ Celecoxib
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Section 4

Question Answer
AspirinTinnitus/ salicylism
AcetominophenHepatic Necrosis
NaproxenIbuprofen + CNS
PhenylbutazoneTOXIC: nephritis, hepatitis, ablastic anemia, granulocytosis
IndomethacinOccult blood loss, close patent ductus arteriosis
CelecoxibClose patent DA
MisoprostolAbortofactive
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Section 5

Question Answer
AspirinNo in chickenpox/flu in kids
DifusinolAsthma
AcetominophenNo for inflame
KeterolacAdditive Side effects with other NSAIDS
Phenylbutazonecardiac, renal, or hepatic dysfunction
IndomethacinNo in preg/ no with warfarin
CelecoxibNo in pregnancy
MisoprotolNo in pregnancy
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