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PATHOLOGY ANTIBODIES IN VARIOUS DISEASES

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medmaestro's version from 2015-09-26 11:59

Section

PATHOLOGY

 

ANTIBODIES IN VARIOUS DISEASES:

 

Autoimmune hepatitis
Autoimmune hepatitis is condition of unknown aetiology which is most commonly seen in young females. Recognised associations include other autoimmune disorders, hypergammaglobulinaemia and HLA B8, DR3.
Type I-Anti-nuclear antibodies (ANA) and/or anti-smooth muscle antibodies (SMA)-Affects both adults and children.
Type II - Anti-liver/kidney microsomal type 1 antibodies (LKM1)-Affects children only.

 

DISEASE ENTITYASSOCIATED SPECIFIC ANTIBODY AGAINST
Systemic sclerosisDNA Topo-isomerase I (Scl 70)
CREST SYNDROMEAnti Centromere
Sjogren syndromeAnti SSa and Anti SSb and Anti Fodrin antibody
Inflammatory myopathies Anti Jo1 antibody
Cold AIHA asso with Mycoplasma pneumonia Anti I-antibody
Cold AIHA asso with Infectious mononucleosis Anti i-antibody
Behçet’s syndrome Anti alpha Enolase of endothelial cells and ASCA in late cases
Crohns diseaseASCA
Rheumatic feverSerum 883- A B-cell alloantigen , Antibody labelled D8/17
Type II MPGN and Partial Lipodystrophy C3 nephritic factor-which binds to alternate complement system C3 convertase and stabilizes it
Rheumatoid arthritisAnti cyclic citrullinate peptide antibody
Mixed connective tissue disease Anti RNP antibodies
HCV infectionAnti Liver-Kidney-Microsomal 1 (LKM 1) antibody
Autoimmune hepatitis Type 1Antinuclear antibody , Anti smooth muscle antibody.
Autoimmune hepatitis Type 2aHigh titre anti LKM
Autoimmune hepatitis Type 2bLow titre anti LKM
Autoimmune hepatitis Type 3Antibody to Soluble liver antigen (SLA)
Primary biliary cirrhosis Anti mitochondrial-E2 subunit of pyruvate dehydrogenase complex
Celiac sprueIgA anti-gliadin ,IgA anti endomysial, IgA anti tissue transglutaminase, IgA anti reticulin antibody
Myasthenia gravis Anti Ach receptor antibody, Anti Muscle specific kinase antibody {MUSK}
Lambert Eaton myasthenic syndromeAnti P/Q type calcium channels
Fischer syndromeAnti ganglioside antibody {GQIb}
Chronic Hepatitis DAnti LKM III
Heparin induced thrombocytopeniaAntibody against complex of heparin with Platelet factor 4 membrane protein
Polyarticular JRARheumatoid factor and Antinuclear antibodies
Pauciarticular JRA Antinuclear antibodies only
Systemic onset JRANo antibodies at all.
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