Patho Quiz Acute Inflammation

laurelmoon718's version from 2015-11-22 00:27


Question Answer
Basement membrane made ofType 4 collagen, Laminin, proteoglycan
Interstitial matrix made offibrillar collagens, elastin, proteoglycan and hyaluronan
Collagen and elastin broken down bymetalloproteases
Clinical manifestations at affected site in acute inflammationcalor, rubor, tumor, dolor, loss of function
What makes up pus?neutrophils

Section 2

Question Answer
Outpouring of aqueous, protein free fluidserous inflammation
Ex of serous inflammationskin blister
Inflammation usually associated with more serious injuryfibrinous inflammation
Fibrinous inflammation has ____ deposits caused by large blood molecules passing through endothelium during injuryfibrin
Inflammation with puspurulent
Pus composed of what three thingsneutrophils, necrotic cells, fluid accumulation

section 3

Question Answer
Prostaglandins fromplatelets, all leukocytes, EC (cell derived, synthesized)
Leukotrienes fromall leukocytes (cell derived, synthesized)
Platelet activating factor fromall leukocytes, EC (cell derived, synthesized)
Activated O2 fromall leukocytes (cell derived, synthesized)
NO frommacrophages (cell derived, synthesized)
Histamine frommast cells, basophils, platelets (cell derived, preformed granules); IgE-R binding, C3a, C5a IL-1, IL-8, chemokines
Serotonin fromplatelets (cell derived, preformed granules); exposed subendo collagen, thrombin, PAF
Lysosomal enzymes fromneutrophils, macrophages (cell derived, preformed granules); alpha-1 antitrypsin keeps in check
Cytokines/chemokines frommacrophage, lymphocytes, EC (cell derived, synthesized)
Complement fromliver (plasma derived, C3a, C5a, C3b, C5b-9=MAC)
Factor XII fromliver (plasma derived, kinin, coagulation/fibrinolysis)

Proinflammatory biochemical mediators and what they do

Question Answer
Prostaglandinspain, fever
C3a and C5aincrease vascular permeability, chemotaxis
Bradykininincrease vascular permeability, pain, vasodilation
IL-8, LB4, MCP-1chemotaxis
IL-1chemotaxis (leukocyte recruitment), fever
TNF-achemotaxis, fever, induces cell death
IL-6proliferation and antibidy production of B cells
PAFvasodilation, sometimes vasoconstriction
histamine, leukotrienes, prostaglandinsedema
C5a, LTB4, IL-8neutrophils (6-24 hrs)
IL-1, TNF-a, MCP-1macrophages (24-48 hrs)

Section 5

Question Answer
Circulatory response, initially vaso___constriction
After vasocontriction, what happenssignificant vasodilation
Purpose of vasodilation after vasoconstrictionslow down local flow
Another circulatory response besides vascular changesincreased permeability
Purpose of increased permeabilityleaking plasma contents into tissue
Leaking plasma contents into tissue akaexudation
Five core changes associated with endothelial cell activationloss of vascular integrity (increased permeability), expression of leukoyte adhesion molecules (P selectin), change from antithrombotic to prothrombotic state, cytokine production, upregulation of MHC molecules
Increased passage of fluid and protein out of microcirculationexudation
Exudation facilitates increased _____ drainagelymphatic
Sluggish blood flow at local site due to fluid loss into exudates and accumulation of RBC'sstasis

Section 6

Question Answer
First cell from blood into local tissueneutrophils
Purpose of cell migration to injury sitephagocytosis and removal of debris
Platelets purposeseal off affected area
Acute inflammation termination includes release of anti-inflammatory cytokines such asTGF-B, IL-10, Macrophages
Acute inflammation termination includes release of anti-inflammatory lipid mediators such asresolvins and protectins
Uncontrolled inflammation can lead totissue necrosis