Patho Quiz Acute Inflammation

gubukapo's version from 2017-09-05 06:25


Question Answer
Basement membrane made ofType 4 collagen, Laminin, proteoglycan
Interstitial matrix made offibrillar collagens, elastin, proteoglycan and hyaluronan
Proteins that are heavily glycosylatedproteoglycans
Protein of ECM produced most often by cellsFibroblasts
Proteins of ECM serve ____ functionstructural
Most abundant protein in bodycollagen
Collagen glycosylated or noyes
Elastin glycosylated or nono
Collagen and elastin broken down bymetalloproteases
Injury usually begins at what levelcellular
cell homicide, unnatural deathnecrosis
death that occurs after extreme physiological conditions or injurynecrosis
death that occurs to a group of adjacent cellsnecrosis
Cell suicide, natural deathapoptosis
Occur as a single cell deathapoptosis
minimal if any inflammatory responseapoptosis
Reduction in size of cellatrophy
increase in size of cellshypertrophy
increased numbers of cellshyperplasia
replacement of one differentiated cell type by anothermetaplasia
Targets and magnitude of inflammation process not always optimal and ____controllable
Clinical manifestations at affected site in acute inflammationcalor, rubor, tumor, dolor, loss of function
What makes up pus?neutrophils
Rigors akashivering
Chills akasearch for warmth

Section 2

Question Answer
Outporuring of aqueous, protein free fluidserous inflammation
Ex of serous inflammationskin blister
Inflammation usually associated with more serious injuryfibrinous inflammation
Fibrinous inflammation has ____ deposits caused by large blood molecules passing through endothelium during injuryfibrin
Inflammation with puspurulent
Pus composed of what three thingsneutrophils, necrotic cells, fluid accumulation

section 3

Question Answer
Prostaglandins frommast cells, leukocytes
Leukotrienes frommast cells, leukocytes
Histamine frommast cells, basophils, platelets
Substance P frommany tissues
Reactive oxygen species fromNitric oxide by leukocytes/granulocytes
Cytokines/chemokines frommacrophage, leukocytes, TNF, IL etc.
Platelet activating factor fromleukocytes, endothelial cells

Proinflammatory biochemical mediators and what they do

Question Answer
Prostaglandinspain, fever
C3a and C5aincrease vascular permeability, chemotaxis
IL-1chemotaxis, fever
TNF-achemotaxis, fever
PAFvasodilation, sometimes vasoconstriction

Section 5

Question Answer
Circulatory response, initially vaso___constriction
After vasocontriction, what happenssignificant vasodilation
Purpose of vasodilation after vasoconstrictionslow down local flow
Another circulatory response besides vascular changesincreased permeability
Purpose of increased permeabilityleaking plasma contents into tissue
Leaking plasma contents into tissue akaexudation
Five core changes associated with endothelial cell activationloss of vascular integrity (increased permeability), expression of leukoyte adhesion molecules (P selectin), change from antithrombotic to prothrombotic state, cytokine production, upregulation of MHC molecules
Increased passage of fluid and protein out of microcirculationexudation
Exudation facilitates increased _____ drainagelymphatic
Sluggish blood flow at local site due to fluid loss into exudates and accumulation of RBC'sstasis

Section 6

Question Answer
First cell from blood into local tissueneutrophils
Purpose of cell migration to injury sitephagocytosis and removal of debris
Platelets purposeseal off affected area
Actue inflammation termination includes release of anti-inflammatory cytokines such asTGF-B, IL-10, Macrophages
Acute inflammation termination includes release of antiinflammatory lipid mediators such asresolvins and protectins
Uncontrolled inflammation can lead totissue necrosis
Viral or protozoan infections, or patients debilitated by dissemiinated cancer, advanced stages of TB, or alcoholismleukopenia
Associated with parasitic infestations, asthma, or allergyeosinophilia
Widespread intravascular blood clotting that manifests as brusises and purpura on skindisseminated intravascular coagulation
severe infections by microorganisms usually bacteriaseptic shock
2 clinical manifestations of septic shockhypotension and tachycardia
2 other systemic complicationsmulti-organ dysfuntion/fauilure, metabolid disturbance
Ex of metabolic disturbanceacidosis