Patho Inflammation Quiz-Chronic Inflammation

laurelmoon718's version from 2015-11-22 00:49

Section 1

Question Answer
Prolonged durationweeks or months
How long does chronic inflammation lastprolonged duration
3 things associated with chronic inflammationinflammation, tissue injury, attempts at repair
Chronic Inflammation significant tissue ____, altered ____, and changes to ____remodeling, physiology, homeostasis
____ abnormal tissue infiltration by cells of immune system such as macrophages and neutrophilspersistent
Continuous release and activities of growth factors and cytokines from damaged tissues and immune system cellsTissue remodeling
Collagen deposits that make up scar tissues and fibrosisfibroblasts
Hypertrophy/plasia are examples of what part of tissue remodelingcell adaptations
Chronic inflammation follows an episode of whatprolonged acute inflammation
Chronic inflammation can begin ____insidiously
T or F. Chronic inflammation begins with manifestation of acute reactions. Can be without, so F

Section 2

Question Answer
Growth signal for keratinocytes and fibroblasts, wound healingEpidermal Growth Factor Alpha (EGF-a)
Signal for hepatocytes and epithelial cell replicationTransforming growth factor a and b (TGF-a and TGF-b)
Signal for only angiogenisis and wound healingVEGF
Signal for chemotaxis for immune system cellsPlatelet-derived growth factor (PDGF)
Signal for activating cell replication processesPlatelet-derived growth factor
Signal for regulation of immune functions and inflammationTNF
Immune system mediatorsInterleukins
Mediators for Wound HealingEGF-a, TGF-a/b, VEGF, PDGF, TNF
Mediators for angiogenesisVEGF and PDGF

Section 3

Question Answer
Scarring akafibrosis
4 outcomes of chronic inflammationExcessive inflammation, Resolution of injury/cure, Scarring/fibrosis, insufficient/defective removal of injurious agents
outcome of chronic inflammation that can lead to emergence of other disorders/diseasesexcessive inflammation
Nearly all chronic disease has some components/contributions from whatchronic inflammation
Proliferation of original cells and tissues to replace lost onestissue regeneration
Tissue regeneration occurs whereonly in very selected tissues
ex of 2 selected tissues where tissue regeneration occursbone marrow, liver
Tissue regeneration dependent of availability of whatadult tissue stem cells
Tissue ____ restores full function of original tissuesregeneration
Tissue ____ is ideal, but rarely occursregeneration
What occurs when tissue regeneration is not possiblerepair
Tissue regeneration can occur in the extracellular matrix. T or F?F
Where can tissue repair occur?everywhere in body
In tissue repair, what is necrotic tissue replaced with?collagen that results in scar tissue formation
Tissue ____ does NOT restore full function of original tissuesrepair
Injurious damage removed early/promptlyscar formation
persistent tissue damage fibrosis
Tissue ____ is not ideal, but commonly occursrepair

Section 4

Question Answer
A tough, dense mass of collagenScar tissue
Bridge or cover across damaged areascar tissue
Scar tissue avascular or vascularavascular
Scarring results in loss of whatnormal physiologic function
ECM remodeling always ____ the tissue structure and never ____ itmodifies, improves
Do tissue regeneration and tissue repair influence each other?they can
An attempt by the immune system to isolate foreign invaders by walling or sealing them offabscess and granuloma
Purulent collection of fluid/pusabscess
Granulomatous inflammation have involvement of whatMacrophages
What are macrophages transformed into in granulomatous inflammationepithelium-like cells
When do granulomatous inflammations include fibroblasts and connective tissueolder granuloma
What cells involved in granulomatous inflammation (not old ones)macrophages, lymphocytes, plasma cells

Section 6

Question Answer
Inflammation occurs on which day0
Proliferation occurs on what day3-4
Granulomatous tissues occur on which day3-4
3 steps of wound healing in orderinflammation, proliferation, remodeling
4 systemic factors that can hinder healingnutrition, metabolic status, impaired circulatory status, hormones/drugs
Ex of nutritional hinderanceVitamin C or protein deficiency
Ex of metabolic status hinderanceDiabetes
Ex of impaired circulatory status hinderanceischemia
3 ex of hormones/drugsglucocorticoid, steroids, sirolimus
Glucocorticoid fromadrenal hormone
Ex of steroidprednisone and sirolimus
4 local factors that can hinder healinginfection, mechanical factors, presence of foreign bodies, size/type/location of wounds
Worse outcomes in small or large woundlarge
More or less vascularized lead to worse outcomes and whyless, less blood supply
generally develop after thermal/traumatic injury that involves deep layers of dermishypertrophic scars
Scar tissue that grows beyond boundaries of original wound and doesn't regresskeloid
Wound healing in excess can cause what to happen to muscles and tendonscontraction