robertojr's version from 2015-11-25 17:33

RBC cont

Question Answer
T/F: Hemoglobin concentration varies by Age, Sex & Pregnancy StatusTrue (normal ranging from 11-13 g/dL)
Normal range for Hemoglobin concentration is ___ to ___ g/dL11-13 (6 mo-5yo children & pregnant women have 11; adult males have 13)
3 mechanisms of Anemia1. Blood Loss 2. Decreased Production 3. Increased Destruction (Hemolysis)
Term describing RBC's with low hemoglobinationHypochromic
Term describing RBC's with normal hemoglobinationNomochromic
____-blasts are relevant to bleeding disordersMegakaryocytes
____-blasts are relevant to AnemiasPro-erythroblasts (and Erythroblasts)
What is the very last step in development before becoming a mature RBC?Reticulocyte
What is the immediate precursor of mature RBC's?Reticulocyte
These cells can be differentiated from RBC's b/c they're bigger, bluer, and have Nucleic acids stillReticulocytes
After losing a lot of blood... what cell would be seen in abnormally high values in the periphery following the body's response?Reticulocytes (baby red blood cells)
What molecule makes up most of RBC's content?Hemoglobin
Concentration of what is used by WHO to classify Anemias?Hemoglobin
Packed RBC volume is akaHematocrit
What Lab test is useful for detecting abnormalities in RBC size and number?Hematocrit
T/F: Red blood cells and all their precursors have nucleiFALSE (RBC's don't but precursors do)
T/F: Red blood cells lack nuclei, but their precursors have nucleiTRUE
Term for abnormal variation in RBC shapePoi-kilo-cytosis
Term for excessive variation in RBC sizeAniso-cytosis
RBC's that are abnormally small in size are referred to as ______MICRO-CYTIC
RBC's that are abnormally large in size are referred to as ______MACRO-CYTIC

clinical features of common anemias

Question Answer
Hypochromic & Microcytic RBC'sIron Deficiency Anemia (insufficient intake or failure to retain by bleeding or other loss)
Normal RBC's but low quantityAnemia of Chronic Disease (cytokine causation)
Enlarged and relatively immature circulating RBC'sMegaloblastic Anemia (B12 or Folate deficiency)
(mechanistic class of Anemias) Hyperbilirubenemia & JaundiceHemolytic Anemia
LeukoerythroblastosisMyelophthisic Anemia (metastatic cancer or granulomatous disease infiltrate of bone marrow)
tear-drop red cells in the peripheral blood.Myelophthisic Anemia (metastatic cancer or granulomatous disease infiltrate of bone marrow)
Low concentrations of WBC's, RBC's & PlateletsAplastic Anemia (original stem cell affected)
Extreme susceptibility to infections, Anemia & Bleeding disorderAplastic Anemia (stem cell progenitor of WBC's, platelets & RBC's affected)
Hypocellularity of bone marrowAplastic Anemia (stem cell progenitor of WBC's, platelets & RBC's affected)
Altered Erythrocyte production --> increased HemolysisThalassemia
Brittle concave fingernails (Koilonchyia)Plummer-Vinson disease (iron deficiency)
“Burning” tongue with Patchy or diffuse erythema, Atrophy of filiform papillae, Taste alteration & Tongue FISSURINGIron deficiency (could also be Candidiasis)
northern European women 30-50 yrs w/ anemia, glossitis, & DysphagiaPlummer-Vinson syndrome
Burning sensation of tongue, lips, taste disturbances, Patchy or diffuse erythema, or pallor; tongue Surface atrophy, LOBULATION... Skin may be yellow-grayPernicious Anemia
gingival bleeding, mucosal petechiae, purpura, ecchymoses; gingival enlargement; mucosal ulcersAplastic Anemia
Reduced Trabeculation, "hair-on-end" appearance of calvaria, and delayed dental eruption are radiographic signs Sickle-Cell
Honeycomb bone pattern, "hair-on-end" appearance of calvaria, and enlarged jaws are radiographic signsThalassemia


Normal Values for Lab #'s
Question Answer
***Red Blood Cells / mL***(N = 3.5-6 million/ml)
***Reticulocyte count (%)***(N = 0.5-1.5%)
***Hemoglobin (g/dL)***(N = 12-18 g/dl)
***Hematocrit (or packed RBCs/ volume)*** (%)(N =) 37-54%
Mean Cell Volume (mm3)(N =) 82-96 mm3
Red Blood Cell Distribution Width (i.e. coefficient of variation in cell volume)(11.5-14.5)
*** platelets/mL***(Normal =) 150-450,000 platelets / mL
***granulocytes/mL***(Normal = 3-8,000)
***reticulocytes/mL***(Normal = 50,000)