ljb20's version from 2016-05-26 17:55

Section 1

Question Answer
3 forms ameloblastomaconventional/multicystic; Unicystic; Peripheral
mutations of ameloblastomamaxilla- SMO mutation Mnd- BRAF
follicular ameloblastoma- histislands with stellate reticulum in center
histo of plexiform ameloblastomalong strings
acanthoma form of ameloblastoma histosquamous metaplasia or stellate reticulum
granular cell form of ameloblastoma histometaplasia to granular cells
desmoplastic form of ameloblastoma histo and locationfibrotic. usually in the ANTEIOR MANDIBLE
unicystic ameloblastomaALWAYS UNILOCULAR. tend be to associated with impacted tooth
adenomatoid odontogenic tumor2nd decade and FEMALE- "snowflake calcifications"=> mixed density radiography in maxillary cuspid region with unerupted canine assocaited - histo = DUCT FORMATIONS
Calcifying odontogenic cyst (CCOT)Under 30 YO- MIXED radiodensity- beta catenin mutation => GHOST CELLS - ameloblast like epithelium with ghost cells with calcificaiton inside. associated with IMPACTED TEETH
Calcifying Epithelial Odontognic tumorOVER 30 YO- Mixed density in MND MOLAR RAMUS- histo= polyhedral cells with intracellular bridging (squamoid like) producing sheets amyloid with LISEGANG RINGS = circular calcifications. ASSOCIATED WITH IMPACTED TEETH
Ameloblastic fibroma/ Fibro- odontomaMALE KIDS - mnd molar / ramus area around CROWN IMPACTED TOOTH - AFO is mixed dense bc it produces tooth like material - Neoplastic epi and CT with IMMAUTRE DENTAL PULP APPEARANCE> difference with ameloblastoma is IMMATURE CT. AF has high chance recurrence and when it does it MALIGNANT. AFO low chance of recurrence. AF= MALES. AFO= max= mnd
Compound/ Complex OdontomaRadio opaq COMPOUND ANTERIOR MAXILLA containing mini teeth. COMPLEX posterior mnd or maxilla with irregular mass of tooth like material
Odontogenic myxomaUNDER 30 in MND. Histo wide spaced fibroblasts mucopolysaccharid minimal collagen
Clear Cell Odontogenic Carcinomaonly malignancy wihtout benign counterpart. symptomatic or not. histo= clear cells
Central Odontogenic FibromaFEAMLES in MAXILLA. associated wiht IMPACTED TOOTH. Simple type vs. WHO type. WHO type has odontogenic epithileum and "droplet" calcification. the Simple type has dystrophic calcification and collagen

Section 2

Question Answer
Central Giant Cell GranulomaOVER 30 FEMALE in the mnd - Tend to CROSS HTE MIDLINE- Scallops roots - same histo as PGCG = giant cells extravasated blood and hemociderin
Central Hemangioma10-20 YO Females in MND - cavernous or capillary aspirate. multilocular usually
MACHOmost likely dx for radiolucency = odontogenic myxoma ameloblastoma central giant cell granuloma central hemangioma OKC
Hyper PTH = BROWN's TUMORmultiple jaw lesions seen. histo- CGCG
Cherubismautosomal dominant disease- early onset with spontaneous resolution by puberty - BILATERAL LESIONS with symmetric expansion. - "LOOKING UP" - histo = similar to CGCG but eosinophillic perivascular cuffing
aneurysmal bone cystTUMOR FEMALES- multilocular in posterior mnd - detect crepitus with palpation and pts feel pain when move head - histo = CGCG BUT also extravasated blood that is sinusoidal.
Fibrous dysplasiaYOUNG DISEASE tends to be UNILATERAL- if not young it NOT FIBROUS DYSPLASIA- mutation in GNAS1- radiographically "GROUND GLASS" and dispalce IAN Superiorally- histo = fibrous stroma containing scattered irregular shaped trabeculae of woven bone. risk of OSTEOSARCOMA
Polyostotic Fibrous DysplasiaEVEN YOUNGER THAN Fibrous dysplasia McCune Albright Syndrome or Jaffe Lichtenstein both have cae au lait spots. age is less then monoostotic. 50% females have precocious puberty by age 4
Ossifying Fibroma3rd or 4th decade FEMALE- molar MND region - mutations in HRPT2 Gene UNILOCULAR mixed density - causes DOWNWARD BOWING of inferior mnd cortex - histo = irregular round or ovoid trabeculae of cementum
Hyperparathyroid Jaw Tumor SyndromeGermline HRPT2 mutation => parathyroid adenoma/ carcinoma/ ossifying fibroma, renale uterine tumor
Osseous DysplasiasDISTINCTLY FEMALE - Periapical = ant mnd. FOD = MULTIQUADRANT bone becomes sclerotic over time and bc of loss BV risk of osteomyelitis. FOCAL has NO RISK FOR RACE others are black. usually 1st molar = mnd
Paget's DiseaseExcessive Bone Deposition/ Resorption = early have fibrous dysplasia then Florrid osseous dysplasi then HYPERCEMENTOSIS. Histo= BFOL like wiht basophillic reversal lines in bone. Jigsaw mosaic pattern. RISK FOR OSTEOSARCOMA
Osteo and ChondrosarcomaCondrosarcoma = MAXILLA. STARBURST PATTERN in radio.
Osteoblastoma and Osteoid Osteomadifferentiated based on SIZE if greater than 2 cm = osteoblastoma. osteoid osteoma is painful but osteoblastoma is NOT. 1st molar mnd region.
OsteomaBenign tumor young adults in MND. histologically = BONE
Gardner Syndrome= FAP = APC gene mutation. intestinal polyposis, abdominal fibromatosis, multiple epidermoid cysts, OSTEOMA ODONTOMAS and SUPERNUMERY TEETH

Section 3

Question Answer
Cleidocranail Dysplasia Runx2 mutation - absent udnerdeveloped clavicles and Contanelles dont close => frontal bossing. Osteopenia/ osteoporosis and SUPERNUMERY TEETH
AchondroplasiaFGFR2 defec autosomal dominant. Large head short limbs normal trunk.
Fibrous DysplasiaGNAS mutation- Hockey stick deformity in legs. predisposed to endocrine tumors. polyostotic==mccune albright
Osteogenesis ImperfectaColalge 1 defect - GENETIC HETEROGENEITY. prone to fracturing long bones but NOT the jaw. Type 1= quantity defect 2= lethal 3= progressively deforming 4= moderately deformed. Blue sclera, hearing loss joints effected skin less elastic. weak bones. DI type 1
HypophosphatasiaTNSALP defect- ALPL gene mutation- rqed to metabolize pyrophosphate ie catalyzes dephosphorylation rxns. Pyrophosphate to phosphate ratio is skewed to pyrophosphate which inhibit HAP foramtion. manifestations= soft bones spontaneous fractures premature tooth loss bc form improer calcium. see LARGE PULP CHAMBERS and CANALS.
OsteopetrosisAUTOSOMAL RECESSIVE- osteoclast defect that wont degrade matrix so have very dense thick bone. Brittle bones bc of that. see "Sandwhich vertebrae" cranail nerves can be trapperd => deafness
McCune AlbrightPolyostotic FD, pigmented skin cafe au lait spots, precocioius puberty and endocrine tumors
ALbert Schonberg diseaseosteopetrosis of ADULTS

Section 4

Question Answer
Enamel Hypoplasiapits on surface of teeth. can manifest if 1) mother has virus during pregnancy (chicken pox, measles, mumps, mono) 2) Celiac disease 3) AI
HypodontiaEctodermal dysplasi or hereditary oligodontia
HyperdontiaCleidocranial dysplsia or FAP
Ectodermal DysplasiaX linked= EDA gene mutation- hypohydrotic ectodermal dysplasia = defects in all ectodermal structures including hair skin teeth nails sweat glands
Otodental syndormesDeafness and GLOBODONTIA
Tricho- dento- osseous syndormesTaurodontism
Oculo-facial-cardio-dental syndromeRadiculomegaly = LONG ROOTS (canines in particular)
AIGenetic heterogeneity- type 1 hypoplastic= pitting. hypomaturation type 2- severe premature attrition with abnormal spacing and small type 3= hypocalcifed= severe discoloration. RADIO= enamel = density of dentin
DIobliterated root canals and chambers
dentin dysplasia type 1only effects roots. radicular dentin defect. Pulps obliterated. teeth normal apperance intraorraly
Dentin dysplasia type 2Coronal dentin defect DSPP mutation probably DI 2
HypophosphatasiaTNSALP mutaiton. no HAP= cementum defect. ENLARGED PULP CAMBERS and CANALS. absent cementum
Regional OdontodysplasiaGHOST TEETH. NOT GENETIC = DEVELOPMENTAL due to ischemia to region of mouth. thin enamel with large pulps

Section 5

Question Answer
dentigerous cystunilocular around crown of impacted tooth attached at the CEJ
eruption cystretained dentigeorus cyst
Residular cystUNILOCULAR retained radicular cyst after extraction. has chance of malignant transformation
Buccal bifurcation cystneed occlusal film UNILOCULAR. inlfmamatiory OG from PDL space not the tooth itself
Lateral Periodontal cystUnilocular developmental cyst in VITAL TOOTH. mnd it bt canine and PM. max it Lateral and canine
Botryoid cystmultiloc lateral Periodontal cyst. histo = thin cuboidal or squamous lining wiht plaque like thickenings with clear glycogen rich cells
Gingival cyst of adultMOST LIKLEY ON BUCCAL GINGIVA. soft tissue coutnerpart of perio cyst. no radiology
OKCcan look like anything. it is a neoplasm. grow in AP not BL direction. Palisading cells with parakeratosis and 8-15 cells thick.
Nevoid Basal Cell Carcinoma SyndromeMutation in PATCH Tumor suppressor autosomal dominant mutation. multiple BCC OKC meduloblastoma intracranial calcifications palmar plantar pitting and bifed ribs
focal osteoporotic bone marrow defectin extraction site it is norma lbone marrow
traumatic bone cystnot a cyst. it a blood clot. MULTILOCULAR SCALLOPING. in MALES YOUNG. teeth are vital
Stafne bone cystMALES post mnd in submnd gland area. unilocular radiolucency below IAN canal in posterior mnd. histologically it glandular tissue
Aneurysmal bone cyst FEMALES it a TUMOR. multilocualr. histologically blood. due to fusion oncogenic protine
Nasopalatine duct cystover 6 mm . oval or heart shaped radiolucency
Incisive papilla cystsoft tissue counterpart of nasopalatine duct cyst
nasolabial cystbilateral fluctuant swelling of nasolabial fold FEMALES OLD. histo = RESPIRATORY EPITHELIUM wiht many goblet cells
epidermoid cystlooks like a pimple. orthokeratinized lining
dermoid cystecto and mesodermal cyst lining. abouve geniomyoid is FOM below is submental
thyroglossal duct cystmidline neck cyst. lining is thyroid tissue. move as swallow. chance for PAPILLARY CARCIONMA
Branchial cleft cystlateral neck cyst ocassionally bilateral NON SPECIFIC CYST LINING WIHT DENSE LYMPHOID TISSEU
Lymphoepitheial cystwaldeyers rin. if in parotid gland it HIV DISEASE

Section 6

Question Answer
MucocoeleRupture of salivary duct. FOM= ranule. most commonly in lower lip. histo= chronic inflammation inside with mucin. MACROPHAGES TAKE UP MUCIN = MUCYPHAGES
Mucous cystTRUE CYST most commonly in major glands. filled wiht mucin and epi lined
Sialolithiasismost common in submnd gland (whartons is twisty) - can block salivary flow => retrograde infection. histo= misshpaen glands with chronic inflammatory infiltrate
Acute bacterial sialodenitisretrograde infeciton due to stasis. increases in pain when eat.
Chronic sialodnitispain burning and swelling when eat. chronic inflamamiton in gland. palliaiton only
chellitis glandularisOlder MALES - sialodenitis of MINOR GLANDS. can be SIMPLE SUPERFICIAL SUPPURATIVE or DEEP SUPPURATIVE. 2 and 3 are painful. due to smoking sunlight diabetes an dpoor oral hygiene. lip is everted and lumpy bumpy in apperance
Necrotizing Sialometaplasiausually POSTERIOR HARD PALATE due to ischemia. see squamous metaplasi of duct and chunk of meat in mouth. MALES
xerostomiaSUBEJCTIVE DIAGONSIS. medicaitons involved Anti histamines anti HTN antidepressants antipsychotics decongestants or anticholinergics
SialodenosisSWELLING - endocinre = diabetes acromegaly or pregnancy. nutritoni= alocholic malnourished bulemic or anoerexic. meds= anti HTN
Mumpsparamyxovirus. BILATERAL PAROTID INVOLVEMNET> pain and enlargment upon eating. can involve testicles and sterility
Cat Scratch diseasebacterial Bartonella henseale= submnd or parotid swelling. it is ifeciton of the LYMPHOID TISSUE inside the gland. self limited disease
SarvoidosisHeerfordts syndrome. parotid enlargment facial nerve palsy uveitis and fever
SjogrenPrimary = sicca = xeropthalmia and xerostomia. 2ndary is sicca and more autoimmune diseases. FEMALES 9:1. Uni or biulateral enlargement. positive ANA postivie SCHIRMER TEST and labial biopsy shows lymphoctic plasma cells. greater than 4 lobules. over 50 cells or more than 1 focal aggreagte in 4 mm. IT IS NOT CHRONICALLY INFLAMMED THO
MONOMORPHIC adenomaOLD FEMALES. 2 types canalicular or BCC
Mucoepidermoid carcinomamost commonly in palate 2nd most minor in palate. recurrent translocation involved. histo is MALIGANT MUCOUS AND SQUAMOUS CELLS. graded based on INNMA. Intracystic perineural necrosis mitosis and anaplasia
adenoid cycstic carcinomaFIRM. major minor evenly. CRIBRIFORM PATTERN w perineurla invasion.
polymorphous low grade adenocarcionmaONLY IN MINOR SALIVARY GLANDS