Path 1- Integumentary Glossary Terms

purplesmurf's version from 2015-10-14 14:04

Da terms, Y'all

Section 1

Question Answer
AcantholysisLoss of cohesion between keratinocytes caused by the breakdown of intercellular bridges
AcanthosisThickening of the spinous cell layer (stratum spinosum) of the epidermis (a SPINEY can)
AcralDistal parts of the extremities
AlopeciaHair loss
AnagenPhase of hair cycle in which hair synthesis (growth) takes place
AnaplasiaLack of cellular differentiation & organization, a feature of neoplastic cells
AngioedemaFAT FACE!!! Vascular reaction involving the deep dermis or subcutis & consisting of edema manifested as giant wheals & caused by dilation + increased permeability of capillaries (deeper version of urticaria)
ApoptosisProgrammed cell death
AtrophyReduction in size of a cell, tissue, organ, or part
Ballooning degenerationMarked intracellular fluid accumulation IN the cells of the epidermis
Blister (vesicle or bulla)Localized collection of fluid usually in or beneath the epidermis
BullaLarge blister (≥10 cm)


Question Answer
Carcinoma in situA malignant neoplasm of epithelial origin that has not invaded through the basement membrane
CatagenTransition phase of the hair cycle between growth & resting phases
CellulitisAn acute bacterial infection of the dermis & subcutis that spreads to surrounding soft tissues & is characterized by erythema, warmth, swelling & pain. The source of the infection is most often a penetrating wound in the area of infection. Cellulitis can also cause fever & enlarged lymph nodes
Comedo (pl comedones)(ZITS!) plug of follicular stratum corneum & dried sebum in a hair follicle that leads to follicular distention
CornificationProduction of stratum corneum by terminal epidermal differentiation
CrustMaterial formed by drying of exudate or secretion on the skin surface
CytokinesSmall molecular weight protein molecules (generally <30 kD) that are mediators of inflammation & growth
DematiaceousNaturally pigmented black or brown mycelium(mass of hyphae) or conidium(broom-looking fungus thing)(so, dark stuff growing bc of fungus)
DermatitisAny inflammation of the skin
DermatophytosisInfection of the stratum corneum of the epidermis, hair, or claws w/ fungi of the genera Microsporum, Epidermophyton, or Trichophyton
DermatosisNon-inflammatory lesion of the skin
DyskeratosisAbnormal, premature, or imperfect keratinization
DysplasiaAbnormal development; term may be used in association w/ a congenital or inherited developmental anomaly or in association w/ an abnormality in maturation of cells w/ in a tissue


Question Answer
EffluviumShedding of hair
ElastosisDegeneration of dermal connective tissue leading to accumulation of elastotic fibers; sometimes seen w/ solar dermatitis
Epidermal collarettePeripheral expanding ring of scale
EpidermitisInflammation of the epidermis
EpidermolysisSeparation of the epidermis from the dermis
Epidermotropic/EpitheliotropicHaving a predilection to enter the epidermis or other epithelial structures as seen w/ Cutaneous T-cell lymphoma (mycosis fungoides)
ErosionLoss of the superficial layers of the epidermis
EruptionRapid development of skin lesion associated w/ redness
ErythemaRedness of skin caused by congestion of capillaries
ExcoriationSuperficial loss of epidermal layers caused by physical trauma (scratching)
ExfoliationShedding of layers or scales
ExogenThe stage of the hair cycle where old hairs are shed while the follicle is returning to the Anagen phase
ExudateFluid, cells, or debris from blood vessels deposited in or on other tissues


Question Answer
FissureCleft or groove
FolliculitisInflammation of a hair follicle
FuruncleCircumscribed, painful nodule (accumulation of pus) in the dermis secondary to follicular rupture (AKA: a Boil)
FurunculosisRupture of follicles usually caused by inflammation, distention, and/or trauma leading to entry of follicular contents into the dermis
GenodermatosisA genetically determined disorder of the skin
GlabrousSmooth skin, hairless skin
HamartomaA localized, tumor-like malformation of mature cells & tissues that includes normal components of the organ in which the hamartoma arises but that is disorganized, present in excess & sometimes larger than normal Usually, one tissue element predominates (eg. follicular hamartoma, vascular hamartoma) A hamartoma is not a true neoplasm because it involves the proliferation of more than one cell type & often includes the development of complex structures such as arteries or follicles
Hydropic degenerationIntracellular fluid accumulation in cells of the basal epidermis
What is the name of the tumor-like malformation that is not a true neoplasm because it involves the proliferation of more than one cell type & often includes the development of complex structures such as arteries or follicles?Hamartoma
HyperkeratosisHistologic term for thickening of stratum corneum
HyperplasiaIncrease in the number of normal cells
HypoplasiaIncomplete development
HypotrichosisLess hair than normal
IchthyosisCongenital skin disorder in which the skin is thickened by scales (hyperkeratosis) that can crack into plates resembling fish scales
ImpetigoBacterial dermatitis characterized by pustules
IndolentSlow growing, a term applied to persistent ulcers on the lips of cats, & sometimes incorrectly called “rodent ulcer,” a term from the human literature used to refer to ulcerated basal cell carcinoma
InduratedHardening of the skin as a result of inflammation or fibrosis (DURable)
InterfaceInflammation arranged in a layer close to & often obscuring the epidermal-dermal junction (interface) & w/ vacuolated (hydropic degeneration) & sometimes apoptotic basal cells; the inflammation can be mild (cell poor) or extensive (cell rich)
IntertrigoDermatitis that develops because of friction between opposing skin surfaces (eg, adjacent folds)


Question Answer
KeratinocytesThe epidermal cells that synthesize keratin & comprise more than 90% of epidermal cells
Keratosis (pl, keratoses)An uncommon to rare circumscribed papular, plaque like, or linear focus of proliferative keratinocytes covered by thick stratum corneum; keratoses can be caused by sun exposure (solar or actinic keratoses) or can be idiopathic (lichenoid, linear, cannon keratoses)
KerionAn intense focal folliculitis usually caused by a dermatophyte infection (KERI's hair looked like shit because her follicles were inflamed by fungi)
Langerhans’ cellsIntraepidermal dendritic antigen-presenting cells
LichenificationThickening of skin w/ accentuation of skin creases caused by marked acanthosis
LichenoidConfusing term that generally refers to a dense zone of dermal inflammation parallel to the epidermis usually w/ out basal cell injury
Lichenoid dermatosis(es)The conventional term for uncommon to rare, often idiopathic, single or grouped papules, plaques, or papillomatous foci covered by scale & histologically composed of epidermal hyperplasia, lichenoid lymphoplasmacytic dermal inflammation, hyperkeratosis & parakeratosis The term dermatitis is probably better than dermatosis as inflammation is present in these lesions
MaculeFlat, circumscribed lesion of altered skin color
MelaninThe dark granular pigment produced by melanocytes that is responsible for the brown coloration of hair, skin, & other tissues such as the iris & choroid of the eye
MelanophageMacrophage containing ingested melanin
Merkel cellA neuroendocrine cell found in the stratum basale
MucinGlycosaminoglycan (GAG), a normal component of the intercellular ground substance of the dermis, consists of protein bound to hyaluronic acid
Myceliuma mass of hyphae
MycetomaA slowly progressive infection of the cutaneous & subcutaneous tissue, fascia, & sometimes underlying bone caused by traumatic implantation of actinomycetes (actinomycotic mycetoma) or fungi (eumycotic mycetoma)
MyxedemaNonpitting edema of the skin because of abnormal deposits of mucin in the dermis
Necrotizing fasciitisAn acute serious life-threatening subtype of cellulitis usually caused by Streptococcus canis bacterial infection & toxin production & located w/ in the subcutaneous fat & fascial planes. The clinical lesions are painful, hot, & swollen areas w/ extensive exudation & necrosis. The condition can progress rapidly & result in systemic shock
NevusCircumscribed malformation of the skin assumed to be of congenital or inherited origin & consisting of any component of the skin The term “hamartoma” is preferred to nevus to avoid confusion w/ the pigmented nevus (mole) that arises in the skin of humans
NoduleA circumscribed, solid elevation of skin (>1 cm) (exophytic)


Question Answer
OnychodystrophyAbnormal formation of the claw
OnychomadesisSloughing of claws
PanniculitisInflammation of subcutaneous adipose tissue
PapuleCircumscribed, solid elevation of skin (<=1 cm)
ParakeratosisRetention of pyknotic(chromatin condensed) nuclei in epidermal cells of the stratum corneum
ParonychiaInflammation of skin around the claws (PARes stuck around the claws)
Pautrier’s microabscessA localized intraepidermal collection of neoplastic lymphocytes characteristic of epitheliotropic lymphoma (mycosis fungoides)
PemphigusA group of cutaneous diseases associated w/ blistering
PhaeohyphomycosisMycotic disease caused by pigmented fungi (dematiaceous fungi) of a variety of genera & species that do not form sclerotic bodies or granules
Pigmentary incontinenceMelanin pigment w/ in dermal macrophages or free in the dermis developing via injury to pigment containing basal layer cells
PlaqueA flat-topped, solid elevation in the skin that occupies a relatively large surface area in comparison w/ its height (≥1 cm)
PustuleSmall, circumscribed accumulation of pus w/ in the epidermis or w/ in a hair follicle
PyodermaPyogenic (pus producing) bacterial infection of the skin


Question Answer
Rodent ulcerA term used in human medicine to define an ulcerative basal cell carcinoma; sometimes used inappropriately in veterinary medicine to refer to an indolent ulcer affecting the lip of cats
ScaleA thin, plate-like accumulation of stratum corneum on the surface of skin
SeborrheaNonspecific term for clinical signs of scaling, crusting, & greasiness Primary seborrhea is a more specific term applied to inherited cornification disorders
SebumSecretion of sebaceous glands
SpongiosisIntercellular edema, which, by widening of the intercellular space & stretching of the “intercellular bridges,” creates a sponge-like appearance to the epidermis
TelogenResting phase of the hair cycle
UlcerFull thickness loss of the epidermis w/ extension into the dermis
UrticariaUsually transient vascular reaction in the upper dermis consisting of edema manifested clinically as wheals (hives); a more superficial version of angioedema
VesicleSmall blister w/ in the epidermis or at or below the dermalepiderma interface (<10 cm)
Vibrissa (pl, vibrissae)Long, coarse hair located about the nose (sinus hair, tactile hair, WHISKERS)
VitiligoAcquired disorder characterized by circumscribed areas of depigmentation in the skin
WhealSmooth, circumscribed, slightly elevated area on skin caused by dermal edema
YeastUnicellular budding fungus

Hair Cycle

Question Answer
AnagenPhase of hair cycle in which hair synthesis takes place
CatagenTransition phase of the hair cycle between growth & resting phases
TelogenResting phase of the hair cycle
ExogenThe stage of the hair cycle where old hairs are shed while the follicle is returning to the Anagen phase